Organic synthesis with fullerodendron as a photocatalysist

以富勒木作为光催化剂进行有机合成

基本信息

批准号：
18550035
负责人：
TSUBOI Sadao
金额：
$ 2.64万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

In this project, the investigator synthesized fullerenc (O60) containing many functional groups, which will become a useful material and photocatalyst. It was applied for photooxidation , ene , and Dials-Alder reactions. And the final aim of the project is development of new organic reactions and its application for the synthesis of biologically active natural products. Fulleren is insoluble in organic solvents and water, In this project, the investigator synthesized fullerene being soluble in organic solvents and water , by connection with dendrimer which contains amino, hydroxyl, and carboxyl groups. Fullerodendron with amido and carboxyl gropus showed ability of production of singlet oxygen and it will be useful for the light dynamic therapy. For example, in the experiment using FILE in vitro , it reduced cancer cells under the irradiation of laser light In addition, the investigator synthesized fullerodendron possessing sugar parts at the end, by connection of anthracene with fullerne the investigator succeeded in the complexation of fullerodendron and calcium carbonate, and in the new development of heterogeneous catalysis. This catalyst promoted the photo dimerization of anthracene dendrimer. The surface of sugar containing fullerodendron consists of optically active parts, so it might be useful for the asymmetric synthesis. This fullerodendron-calcium carbonate complex could act as a good catalyst of photooxidation reaction by singlet oxygen. For example, hydroxy unsaturated lactones from furan carboxylic acids, hydroperoxides from various olefins, and sulfoxides from sulfides were prepared in good yields by using this catalyst.

在这个项目中，研究人员合成了包含许多官能团的Fullerenc（O60），这将成为有用的材料和光催化剂。它被用于光氧化，ENE和拨号反应。该项目的最终目的是开发新的有机反应及其用于合成生物活性天然产品的应用。富勒伦不溶于有机溶剂和水，在这个项目中，通过与含有氨基，羟基和羧基的Dendrrimer连接，研究人员合成了富勒烯在有机溶剂和水中。带有amido和羧基grop的FullerOdendron显示出单线氧的产生能力，这对于轻型动态疗法将很有用。例如，在使用File的实验中，它在激光光的照射下还会降低癌细胞，此外，研究人员通过将蒽与Fullerne的连接连接到末端，合成了富集的富集，调查员成功地将Fullerodendron和Fullerodendron和Fullerodendron和Fullerodendron和Fullerne连接起来碳酸钙，以及异质催化的新发展。该催化剂促进了蒽树突聚合物的照片二聚化。含有富甲的糖的表面由光学活性部件组成，因此对于不对称合成可能很有用。这种富富甲酸碳酸盐复合物可以充当单线氧的光氧化反应的良好催化剂。例如，通过使用该催化剂以良好的产量制备了来自呋喃羧酸的羟基非饱和内酯，来自各种烯烃的氢过氧化物和硫化物的亚氧化物。