Sympathetically mediated dental pain and its control

交感神经介导的牙痛及其控制

基本信息

批准号：
17591984
负责人：
SASANO Takashi
金额：
$ 2.08万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591984/
关键词：
Dental pain Sympathetic nerve Pulpitis Pain control axonal transport of WGA-HRP

项目摘要

1. Purpose Mastication needs cooperation of masticatory muscles, but the exact role of the each muscle for mastication is not completely clear. The purpose of this study was to evaluate the change of masticatory muscles under the unilateral masseter muscle dysfunction induced by Botulinum toxin A (BTXA) injection in rabbits. BTXA binds to presynaptic nerve endings and inhibits the release of acetylcholine, leading to temporary partial denervation and reduction of muscle fiber.2. Materials and Methods White Japanese rabbits were injected with 10 units of BTXA into the left masseter muscle. The effect of a neuromuscular blockade of masseteric activity was evaluated with serial computer tomography (CT) scans with 0.63mm slice thickness and 0.1mm slice interval taken after 4 weeks.3. Results The masseter muscle size of BTXA injected was reduced to about 80% against the control side. This indicated the morphologic change caused by the neuromuscular blockade.4. Coclusion To study the exact role of each muscles for mastication, masseter mucle dysfunction was made by BTXA injection into the masseter muscle. The most suitable dose, timing and the degree of dysfunction were established. The elrctro-myography is considered to investigate the functional change. This animal model helps the understanding of the mechanism of tempolo-mandibular dysfunction.

1。目的咀嚼需要咀嚼肌肉的合作，但是每个肌肉在咀嚼中的确切作用尚不完全清楚。这项研究的目的是评估兔子注射肉毒杆菌毒素A（BTXA）注射诱导的单侧咬肌功能障碍下咀嚼肌的变化。 BTXA与突触前神经末端结合并抑制乙酰胆碱的释放，从而导致暂时的部分神经神经和肌肉纤维的减少。2。材料和方法将白色的日本兔子注入了10个单位的BTXA中，左手ktxa肌肉。通过串行计算机断层扫描（CT）扫描评估了asteteric活性的神经肌肉阻滞的影响，其厚度为0.63mm，厚度为0.63毫米，在4周后进行了0.1mm切片间隔3。结果，注射的BTXA的咬肌大小降低到对照侧的80％。这表明神经肌肉阻滞引起的形态变化4。研究每种肌肉在咀嚼中的确切作用，通过注射BTXA对咬合肌肉的注射使咬合粘膜功能障碍。建立了最合适的剂量，时机和功能障碍程度。 Elrctro-gromography被认为是为了研究功能变化。该动物模型有助于理解tempolo-mandfular功能障碍的机理。