Development of percutaneous right heart assist system by using axial flow pump

轴流泵经皮右心辅助系统的研制

基本信息

批准号：
06557074
负责人：
NAKATANI Takeshi
金额：
$ 4.99万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557074/
关键词：
axial flow pump right heart assist percutaneous venous insertion

项目摘要

Right ventricular (RV) function is a limiting facotr to maintain systemic circulation for circulatory assist. There is, however, no easy way to institute RV assist, such as an intraarterial axial flow pump (Hemopump) for left heart assist. In this reseatch, new RV assist system by intravenous use of an axial flow pump was developed and its feasibility and hemodynamic effect was examined. A pump system was developed with an outflow cannula and an impeller which were newly designed for intravenousm insertion with a driving system of Hemopump. The pump system characteristics using goat blood of hematocrit at 26% indicated that maximum flow at a pressure differential against 40 mmHg is 3.2 1/min at a pump speed of 28,000 rpm. The pump was tested in adult goats by intravenous insertion through a 14 mm low porosity graft anastomosed to the infrarenal inferior vena cava. The pump was advances unitil the tip of cannula was positioned at the main pulmonary artery by using a balloon catheter duidance under fluoroscopy. In animal experiments, pump insertion was performaed without complications. In chronic studies using adult goats for up to 48 hours, levels of plasma hemoglobin and platelet counts were acceptable and no prominent daamage was foung in heart tissues. Based on this study, an axial flow pump positioned in the right heart introduced through an intravenous approach is practicable and affords adequate assist for right heart.

右心室（RV）功能是维持循环辅助的体循环的限制因素。然而，没有简单的方法来建立右心室辅助，例如用于左心辅助的动脉内轴流泵（Hemopump）。在这项研究中，开发了通过静脉使用轴流泵的新型右心室辅助系统，并检验了其可行性和血流动力学效应。开发了带有流出插管和叶轮的泵系统，该泵系统是新设计的用于静脉注射的泵系统，带有血泵的驱动系统。使用血细胞比容为 26% 的山羊血的泵系统特性表明，在泵速为 28,000 rpm 时，压差为 40 mmHg 时的最大流量为 3.2 1/min。通过与肾下下腔静脉吻合的 14 毫米低孔隙率移植物进行静脉内插入，在成年山羊中对该泵进行了测试。在透视下使用球囊导管将泵推进直至插管尖端定位在主肺动脉处。在动物实验中，泵插入没有出现并发症。在使用成年山羊长达 48 小时的长期研究中，血浆血红蛋白和血小板计数的水平是可以接受的，并且心脏组织中没有发现明显的损伤。根据这项研究，通过静脉途径引入位于右心的轴流泵是可行的，并且可以为右心提供足够的帮助。