The association offunctional gene polymorphisms with tbe progression of liver fibrosis in chronic hepatitis C.

功能基因多态性与慢性丙型肝炎肝纤维化进展的关系.

• 批准号: 17590641
• 负责人: MURAWAKI Yoshikazu
• 金额: $ 2.43万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590641/
• 关键词: chronic hepatitis; liver fibrosis; genotype; MMP-1; MMP-3; MMP-9; TGF-β1; IL-1β; MMP-2; MMP-7; IL-1RN; IL-1B

In chronic hepatitis C, the interindividual difference in responses against the hepatic necroinflammation appears to be important in the progression of liver fibrosis. This study was to examine the possible association of MMP-1 -1607 1G/2G, MMP-2. -1306 C/T, MMP-3 -1171 5A/6A, MMP-7 -181 A/G, MMP-9 -1562 T/C, TGF-βl +819 T/C, IL-lβ -511 C/T, IL-1RN VNTR polymorphisms with the progression of liver fibrosis in Japanese patients with hepatitis C virus-related chronic liver disease, using cross-sectional and longitudinal study designs. We examined 93 chronic hepatitis C patients and 90 liver cirrhosis C patients. The chronic hepatitis patients were divided into progressive fibrosis and non-progressive fibrosis groups. Gene lymorphisms were analyzed using a polymerase-chain reaction-based assay. In the cross-sectional study, the MMP-1 2G/2G homozygotes and MMP-9 C/C homozygotes were significantly more in cirrhosis group than in chronic hepatitis group, whereas other genotypes showed no significant differences. In the longitudinal study, MMP-3 5A carriers and TGF-β1 T carriers were significantly more in the progressive fibrosis group than in non-progressive fibrosis group, whereas other genotypes showed no significant differences. These findings suggest that MMP-1, MMP-3, MMP-9 and TGF-131 genotypes account for some of the variability in the progression of chronic hepatitis C.

在慢性肝炎C中，在响应坏死症中的反应中的个体差异似乎在ER纤维化的进展中很重要。 T，MMP-3 -1171 5A/6A，MMP-7 -181 A/G，MMP-9 -1562 T/C，TGF-βL+819 T/C，IL-Lβ-511 C/T，IL- 1RN日本肝炎中肝纤维的进展的VNTR多态性与CVIRUS相关的慢性肝病S截面和纵向研究设计。 。进行性纤维化组中的纤维化组比非促进性的Firousis组更多，而其他基因型在慢性肝炎的进展中没有显着差异。

项目成果

MMP-2遺伝子多型と肝線維化進行との関連:MMP-9との関連

MMP-2基因多态性与肝纤维化进展的关联：与MMP-9的关联

• 发表时间: 2007
• 期刊: 薬理と治療 35
• 作者: 大谷英之;他
• 通讯作者: 他

Relationship between hepatic fibrosis or carcinogenesis and the matrix metalloproteinase-7 gene polymorphism

基质金属蛋白酶7基因多态性与肝纤维化或癌变的关系

• 发表时间: 2007
• 作者: Mandai;M.;Okamoto;K.;Mimura;K.;Murawaki;Y;Kinya Okamoto;万代真理;Ohtani Hideyuki
• 通讯作者: Ohtani Hideyuki

C型慢性肝炎患者での肝線維化進展とマトリックス分解酵素およびインターロイキン-1Bの遺伝子多型との関連

慢性丙型肝炎患者肝纤维化进展与基质降解酶、白细胞介素1B基因多态性的关系

• 发表时间: 2006
• 期刊: 薬理と治療 34
• 作者: Ohtani;H.;Mandai;M.;Okamoto;K.;Maeda;N.;Murawaki;Y;万代真理 他
• 通讯作者: 万代真理 他

Association of functional gene polymorphisms of interleukin-1β and transforming growth factor-β1 with the progression of liver fibrosis in Japanese patients with hepatitis C virus-related chrnic liver disease.

白细胞介素-1β和转化生长因子-β1功能基因多态性与日本丙型肝炎病毒相关慢性肝病患者肝纤维化进展的关系。

• 发表时间: 2007
• 期刊: Yonago Acta med 35
• 作者: Mari Mandai;et. al.
• 通讯作者: et. al.

Relationship between hepatic fibrosis or carcinogenesis and the matrix metalloproteinase-7 gene polymorphism.

肝纤维化或癌变与基质金属蛋白酶7基因多态性的关系。

• 发表时间: 2007
• 作者: Mandai;M.;Okamoto;K.;Mimura;K.;Murawaki;Y;Kinya Okamoto;万代真理;Ohtani Hideyuki;Hideyuki Ohtani
• 通讯作者: Hideyuki Ohtani