Effects of physical training and detraining on sympathetic neural regulation of cardiovascular system

体能训练与放松训练对心血管系统交感神经调节的影响

基本信息

批准号：
17500448
负责人：
SAITO Mitsuru
金额：
$ 2.36万
依托单位：
Toyota Technological Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

It is well known that physical training improves cardiovascular regulation but it is not clear how long the improved regulation persists after exercise training. This project attempted to investigate the adaptive change in sympathetic nervous activity (MSNA), which plays an important role in the control of cardiovascular regulation during exercise, to exercise training and detraining. Healthy volunteers performed high intensity handgrip exercise training for four weeks. MSNA was recorded from the tibial nerve by a microneurography technique during fatiguing static handgrip exercise and following post-exercise forearm occlusion (PEFO).Findings :1. MSNA increased in relation to the duration of handgrip exercise time and reached its maximal level at the onset of fatigue. During PEFO the MSNA response was greater than observed in the resting, pre-exercise control level.2. The MSNA response at the onset of fatigue was increased post-training compared to pre-training, while the MSNA response to PEFO was unchanged post-training.3. After four weeks detraining, the MSNA response at the onset of fatigue decreased compared to the immediate post-training and responses and the magnitude of the detraining responses remained unchanged for up to one year The MSNA response to PEFO was unchanged by training. In conclusion, although central command and muscle reflex are factors that can enhance MSNA during muscle contraction, the muscle metaboreflex-induced increase in the MSNA response to PEFO was not modulated by resistance training. On the other hand, resistance training increased central command and this effect enhanced the MSNA response transiently.

众所周知，体育锻炼可以改善心血管调节，但尚不清楚运动训练后改善的调节持续多长时间。该项目试图研究交感神经活动（MSNA）的适应性变化，该项目在锻炼过程中的心血管调节中起着重要作用，以进行运动训练和努力。健康的志愿者进行了高强度的手夹运动训练四个星期。在疲劳的静态手绘运动过程中，通过微功能学技术从胫骨神经记录MSNA，并在运动后前臂闭塞（PEFO）（PEFO）。 MSNA随着手工束运动时间的持续时间而增加，并在疲劳发作时达到其最大水平。在PEFO期间，MSNA反应大于在静止，运动前控制水平中观察到的2。与训练前相比，疲劳发作时的MSNA反应增加了训练后训练，而对PEFO的MSNA反应在训练后不变。3。四周减弱后，与直接的训练后和反应相比，疲劳发作时的MSNA反应减少了，而降解反应的大小保持不变，长达一年，MSNA对PEFO的响应对PEFO的响应没有通过训练而改变。总之，尽管中央指挥和肌肉反射是可以在肌肉收缩过程中增强MSNA的因素，但肌肉代谢反射诱导的MSNA对PEFO响应的增加并未受到阻力训练的调节。另一方面，阻力训练增加了中心命令，这种效应瞬时增强了MSNA响应。