Higy- resolution MRI-aided analysis of cortical circuit in monkey brains

猴脑皮层回路的高分辨率 MRI 辅助分析

• 批准号: 17500202
• 负责人: NAKAHARA Kiyoshi
• 金额: $ 2.41万
• 依托单位: National Center of Neurology and Psychiatry (2006-2007)The University of Tokyo (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500202/
• 关键词: Cerebral Cortex; Neuronal Circuit; Magentic Resonance Imaging; Microelectrode Recording; 単一神経細胞記録; 局所神経回路; 微小電極; 核磁気共鳴画像法

The localization of microelectrode recording sites in the layers of primate cerebral cortex permits the analysis of relationships between recorded neuronal activities and underlying anatomical connections. We have developed a magnetic resonance imaging method for precise in vivo localization of cortical recording sites. In this method, the susceptibility-induced effect thickens the appearance of the microelectrode and enhances the detectability of the microelectrode tip, which usually occupies less than a few percent of the volume of an image voxel. In a phantom study, the optimized susceptibility-induced effect allowed tip detection with single-voxel accuracy. We applied this method to recording microelectrodes inserted into the brains of macaque monkeys, and localized the microelectrode tip at an in-plane resolution of 150 um within the cortex of 2-3 mm in thickness. Subsequent histological analysis validated the single-voxel accuracy of the in vivo tip localization. This method opens up a way to investigate information flow during cognitive processes in the brain.

微电极记录位点在灵长类动物大脑皮层层中的定位允许分析记录的神经元活性和基础解剖连接之间的关系。我们开发了一种磁共振成像方法，用于精确的皮质记录位点体内定位。在这种方法中，敏感性诱导的效果增厚了微电极的外观，并增强了微电极尖端的可检测性，该尖端通常占用图像体素体积的百分之几不到几％。在一项幻影研究中，优化的敏感性诱导的效果允许单腔精度检测尖端检测。我们将此方法应用于记录插入猕猴大脑中的微电极，并将微电极尖端定位在厚度为2-3 mm的皮质内的平面内分辨率为150 um。随后的组织学分析验证了体内尖端定位的单素精度。这种方法开辟了一种研究大脑认知过程中信息流的方法。

项目成果

MRI in monkeys:multi-modal links between human fMRI and macaque neurophysiology

猴子 MRI：人类功能磁共振成像和猕猴神经生理学之间的多模式联系

• 发表时间: 2007
• 期刊: Trends in Cognitive Sciences 11
• 作者: Wenxi Chen;Daming Wei;Shuxue Ding;Michael Cohen;Hui Wang;Shigeru Tokinoya;Naotoshi Takeda;Teppei Matsui;Kiyoshi Nakahara
• 通讯作者: Kiyoshi Nakahara

4.7 T MRI-based detection of the tip of an electrode in monkey cortex

4.7 基于 T MRI 的猴皮层电极尖端检测

• 发表时间: 2005
• 作者: Koyano W.K.;et. al.;Teppei Matsui
• 通讯作者: Teppei Matsui

A non-magnetic mini-manipulaor for an MRI-based method for localization of a microelectrode tip within monkey cerebral cortex

一种用于基于 MRI 的猴子大脑皮层内微电极尖端定位方法的非磁性微型操纵器

• 发表时间: 2007
• 作者: Nakahara K.;et. al.;Matsui T.;Nakahara K.;Matsui T.;Kenji W.Koyano
• 通讯作者: Kenji W.Koyano

MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy

• DOI: 10.1038/nmeth987
• 发表时间: 2007-02-01
• 期刊: NATURE METHODS
• 影响因子: 48
• 作者: Matsui, Teppei;Koyano, Kenji W.;Miyashita, Yasushi
• 通讯作者: Miyashita, Yasushi

Program No.456.10. 4.7 T MRI-based detection of the tip of an electrode in monkey cortex.

程序编号 456.10。

• 发表时间: 2005
• 期刊: 2005 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience Abstract, 2005. (CD-ROM)
• 作者: Nakahara K.;et. al.;Matsui T.;Nakahara K.;Matsui T.
• 通讯作者: Matsui T.