Relationship between lifestyle-related diseases in childhood and the risk for atherosclerotic coronary heart disease in adulthood (studies on lipoprotein abnormality, adipocytokine, vascular endothelial function and related genes)

儿童期生活方式相关疾病与成年后动脉粥样硬化性冠心病风险的关系（脂蛋白异常、脂肪细胞因子、血管内皮功能及相关基因研究）

基本信息

批准号：
17390303
负责人：
OHTA Takao
金额：
$ 10.04万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Many studies have shown that life-style related disorders are risk factors for atherosclerotic coronary heart diseases (ACHD). The pathological arterial sclerosis lesion is present in children, and it is very likely that the development of atherosclerotic lesion is accelerated with the presence of life-style related diseases even in children. Thus, in the present study, we studied the relationship between body weight and serum concentrations of adipocytokines in school children and neonates. In schoolchildren, all adipocytokines evaluated (adiponectin, leptin, Il-6, IL-18, IL-1β) were positively correlated with body weight except for adiponectin. Adiponectin was inversely correlated with body weight These findings were similar to those in adults, thereby suggesting that overweight was a risk factor for ACHD even in children. Differed from school children, serum concentrations of adiponectin were positively associated with body weight in preterm and term infants. To date, some roles of … More adipocytokines such as IL-6 and TNF-α have been highlighted in the inverse correlation between adiponectin and body weight in adults. It has been shown that IL-6 and TNF-α reduce the secretion of adiponectin from adipocytes. Some kinds of inflammation in adipose tissue might contribute to the inverse correlation between adiponectin and body weight. If inflammation or levels of pro-inflammatory adipocytokines were not elevated in adipose tissue, adiponectin secretion from adipocytes might not be reduced. Since the increase in the body weight of the fetus during late pregnancy is a physiological development, it is reasonable to consider that an increase in adipose tissue at this stage might not accompany the inflammation in adipose tissue. Furthermore, the ratio of high-molecular adiponectin (active adiponectin) to total adiponectin was significantly smaller in preterm infant that that in term infant. As adiponectin was secreted from adipocytes, our findings suggest that development of adipose tissue in preterm infants might be different from term infant. This may explain the relation of low birth weight to future development of ACHD. Less

许多研究表明，生活方式相关的疾病是动脉粥样硬化冠心病（ACHD）的危险因素。儿童存在病理性艺术硬化病变，即使在儿童中，动脉粥样硬化病变的发展也很可能会加快生活方式相关疾病。在演讲研究中，我们研究了小学生和新生儿脂肪细胞因子的体重与血清浓度之间的关系。在学童中，所有评估的脂肪细胞因子（脂联素，瘦素，IL-6，IL-18，IL-1β）均与体重呈正相关。这些发现与成年人相似，脂联素与体重成反比，从而表明超重是ACHD的危险因素，即使在儿童中也是如此。与小学生不同的是，脂联素的血清浓度与早产和年龄婴儿的体重呈正相关。迄今为止，在成年人的脂联素和体重之间的反相关性中，突出了一些……更多的脂肪细胞因子（例如IL-6和TNF-α）的作用。已经表明，IL-6和TNF-α降低了脂肪细胞中脂联素的分泌。脂肪组织中的某些炎症可能有助于脂联素和体重之间的反相关性。如果脂肪组织中的炎症或促炎性脂肪细胞因子的水平未升高，则可能不会降低脂肪细胞的脂联素分泌。由于怀孕后期胎儿体重的增加是一种身体发育，因此可以合理地认为，此阶段脂肪组织的增加可能不会参与脂肪组织的炎症。此外，在早产婴儿中，高分子脂联素（活性脂联素）与总脂联素的比率明显小得多。由于脂联素是从脂肪细胞中分泌的，因此我们的发现表明，早产儿的脂肪组织的发展可能与术语婴儿不同。这可能解释了低出生体重与ACHD未来发展的关系。较少的