The tooth movement to the artificial alveolar cleft closed by biological materials of calcium phosphate

牙齿向磷酸钙生物材料封闭人工牙槽裂的移动

• 批准号: 16591979
• 负责人: MATSUI Keiko
• 金额: $ 2.29万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16591979/
• 关键词: biological material; octacalcium phosphate; bone regeneration; artificial bone defect; beagle dog; 人工的顎骨欠損

This study was carried out in order to investigate whether biological materials containing calcium phosphate improve bone regeneration in artificial bone defects in beagles. A scaffold constructed from synthetic Octacalcium phosphate (OCP) and collagen sponge (OCP-Collagen discs: φ9 mm×1 mm) was implanted into three types of bone defect. A critical bone defect (20 mm in diameter) in the dog calvarium, enlarged tooth sockets after extraction of bilateral maxillary third incisors, and an artificial alveolar cleft were prepared.On radiographic examination, the defect in the calvarium implanted with 10 OCP-Collagen discs showed radio-opacity within 6 months, while the control, defects implanted with 10 collagen discs remained radiolucent.The alveolar ridge was flat at the extracted tooth sockets implanted with OCP-Collagen discs, as compared with the concave shape seen in the control side without implantation.Abundant bone regeneration was seen at the artificial alveolar cleft within 4 months after implantation of COP-Collagen discs.The X-ray diffraction (XRD) patterns of implanted OCP-Collagen samples were almost the same as those of intact bone from beagles.The present study suggests that OCP-Collagen composites can improve bone regeneration in medium-sized experimental animals, such as dogs.

进行这项研究是为了研究含有磷酸钙的生物学材料是否改善了小蛋黄中人造骨缺损中的骨骼再生。由磷酸合成八钙（OCP）和胶原蛋白发起人（OCP-胶原蛋白盘：φ9mm x 1 mm）构建的脚手架植入了三种类型的骨缺损。犬钙钙钙库中的临界骨缺损（直径为20毫米），提取双侧上颌第三个切口后，牙齿插座扩大，制备了人工肺泡裂。在放射线学检查中，钙钙的缺陷，钙钙植入10 ocp-collagen disce的calvarium缺陷，在6个月内，同时置于6个月内，同时置于6个月内的距牙槽脊是在植入OCP-胶原椎间盘植入的提取的牙齿插座处平坦的，与没有植入的对照侧看到的凹形形状相比，在植入X射线diffraction（X-ray diffacters ocp ocp ocp ocp ocp ocp ocp ocp ocp ocp ocp ocp ocp the mafteragolal a clefteriation dy the mafteralloal骨再生均已看到。目前的研究表明，OCP-胶原复合材料可以改善中型实验动物（例如狗）的骨骼再生。

项目成果

Clinical study on eruption of permanent canines after secondary alveolar bone grafting

• DOI: 10.1597/03-113.1
• 发表时间: 2005-05-01
• 期刊: CLEFT PALATE-CRANIOFACIAL JOURNAL
• 作者: Matsui, K;Echigo, S;Chiba, M
• 通讯作者: Chiba, M

OCP-Collagen複合体の人工的骨欠損部への応用

OCP-胶原蛋白复合物在人工骨缺损中的应用

• 发表时间: 2006
• 作者: 松井桂子;他5名
• 通讯作者: 他5名

顎裂部への骨移植後に永久犬歯を開窓し萌出誘導した一例

下巴裂口植骨后恒犬开窗萌出的病例。

• 发表时间: 2007
• 期刊: 日本口蓋裂学会雑誌 32
• 作者: 松井桂子;他3名
• 通讯作者: 他3名

The application of octacalcium phosphate (OCP)collagen composites to the artificial bone defects.

磷酸八钙（OCP）胶原复合材料在人工骨缺损中的应用

• 发表时间: 2006
• 作者: Matsui Keiko;ed. al.
• 通讯作者: ed. al.

顎裂部骨移植後の咬合形成-延長ブリッジを応用した一例-

颌裂骨移植后的咬合形成 - 应用延长桥的示例 -

• 发表时间: 2006
• 期刊: 東北大学歯学雑誌 25・1
• 作者: 松井桂子;他3名;松井桂子
• 通讯作者: 松井桂子