Seroepidemiological study of stomach cancer in China

我国胃癌血清流行病学研究

• 批准号: 05042001
• 负责人: FUKAO Akira
• 金额: $ 2.05万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05042001/
• 关键词: stomach cancer; pepsinogen; Helicobacter pylori; beta-carotene; chronic atrophic gastritis; seroepidemiology

A seroepidemiological study in Shenyang city, China, was performed to examine the correlation between several serum markers (pepsinogen I and II, IgG anti-Helicobacter pylori antibody and beta-carotene) and stomach cancer.1. Distribution of serum markers in the populationSerum samples were collected randomly from the blood donors living in Shenyang city. Fifty samples by age-group (20-29, 30-39, 40-49, 50-59) and sex were to be collected, and finally 380 samples were collected. Of these 280 samples were assayed.1) Pepsinogen I and II : Serum level of pepsinogen I of the samples from Shenyang was higher in males and lower in females than those from Miyagi Prefecture. The prevalence of chronic atrophic gastritis determined by pepsinogen was lower in Shenyang than in Miyagi.2) H.pylori antibody : The prevalence of H.pylori infection is lower in Shenyang than in Miyagi, especially among males.3) Chronic atrophic gastritis and H.pylori infection : Odds ratio of chronic atrophic gastritis for the subjects having H.pylori antibody was estimated at 9.9.4) Beta-carotene : No difference in the level of beta-carotene was observed between Shenyang and Miyagi.2. Case-control studyCase subjects were the patients with stomach cancer newly diagnosed in the hospital in Shenyang, and control subjects were the patients with the diseases other than cancer. Fifty cases and 150 controls have been collected until now.Preliminary results show that family history of stomach cancer, having diet irregularly, favoring salt foods, present smoking etc. increased the risk of stomach cancer and meat, eggs, green vegetables, fruits etc. decreased the risk. Analyses including the serum markers have not yet performed since all samples will be assayed at the same time after the samples reach to objective number (200 case and 600 controls).

在中国沉阳市进行了一项血清流行病学研究，探讨了几种血清标志物（胃蛋白酶原I和II、IgG抗幽门螺杆菌抗体和β-胡萝卜素）与胃癌之间的相关性。 1．人群血清标志物分布 血清样本是从沉阳市居住的献血者中随机采集的。按年龄组（20-29、30-39、40-49、50-59）和性别收集 50 份样本，最终收集 380 份样本。对这280个样品进行了检测。1)胃蛋白酶原I和II：沉阳样品中胃蛋白酶原I的血清水平与宫城县相比，男性较高，女性较低。胃蛋白酶原测定的慢性萎缩性胃炎患病率沉阳市低于宫城县。2）H.pylori抗体：沉阳市H.pylori感染率低于宫城县，尤其是男性。3）慢性萎缩性胃炎和H.pylori抗体：沉阳市H.pylori感染率低于宫城县。幽门螺杆菌感染：具有幽门螺杆菌抗体的受试者患慢性萎缩性胃炎的优势比估计为 9.9.4) β-胡萝卜素：沉阳和宫城之间β-胡萝卜素水平没有差异。2．病例对照研究病例对象为沉阳市医院新诊断的胃癌患者，对照对象为患有癌症以外疾病的患者。目前已收集50例病例和150例对照。初步结果显示，胃癌家族史、饮食不规律、喜食咸食、经常吸烟等会增加胃癌的患病风险，而肉、蛋、绿色蔬菜、水果等则增加。降低了风险。包括血清标志物在内的分析尚未进行，因为所有样本将在样本达到目标数量（200 个病例和 600 个对照）后同时进行检测。