A comprehensive study on laryngeal neuroregulation and it's dysfunction

喉神经调节及其功能障碍的综合研究

• 批准号: 16390492
• 负责人: HISA Yasuo
• 金额: $ 8.96万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390492/
• 关键词: larynx; neuronal regulation system; TRPV; α-gustducin; FGF1; TAF II 250; airway clock genes; 中枢性投射; 知覚受容器; 過誤神経支配; 基本転写因子; 痙攣性発声障害; transsynaptic tracer; コリン作動性神経; 知覚受容体; 衛星細胞; 時計遺伝子; 疑核; 節状神経節

Laryngeal neuroregulation is essential in such functions as respiration, deglutition and phonation, which are vital for human survival and social participation. One of the primary objects of laryngeal research has been to seek a better understanding of the laryngeal nervous system. Our knowledge has advanced considerably through research in the past, but much is still poorly understood, and advances in scientific technology has revealed new issues to be studied. The present is a comprehensive and systematic study on the following contemporary issues, using and combining various methods.1.Localization of TRPV1 and TRPV2 in laryngeal sensory neurons.2.Expression and age related changes in expression of α-gustducin in the larynx.3.Expression of FGF1 in the dorsal nucleus of the vagal nerve and nucleus hypoglossus.4.Expression of FGF1 in cholinergic neurons innervating the larynx.5.Expression of TAF-250 in the laryngeal innervation.6.Expression and vagal control of clock genes in the airway.

喉部神经调节对于呼吸、吞咽和发声等功能至关重要，而这些功能对于人类生存和社会参与至关重要。喉部研究的主要目标之一是寻求对喉部神经系统的更好理解。通过过去的研究，但仍然知之甚少，科学技术的进步也揭示了新的问题需要研究，目前正在综合运用多种方法对以下当代问题进行全面、系统的研究：1.本土化。喉部感觉神经元中的TRPV1和TRPV2。2.喉部α-味觉素的表达及年龄相关的表达变化。3.迷走神经背核和舌下核中FGF1的表达。4.胆碱能神经元中FGF1的表达支配喉部。5.TAF-250 在喉部神经支配中的表达。6.表达和迷走神经气道中时钟基因的控制。

项目成果

Age-related expression of a-gustducin in the rat larynx.

大鼠喉中 a-gustducin 的年龄相关表达。

• 发表时间: 2006
• 期刊: Ann Otol Rhinol Laryngol 115-5
• 作者: Nishio T;et al.
• 通讯作者: et al.

Age-related expression of α-gustducin in the rat larynx.

大鼠喉中 α-gustducin 的年龄相关表达。

• 发表时间: 2006
• 期刊: Ann Otol Rhinol Laryngol 115・5
• 作者: Nishio T;et al.
• 通讯作者: et al.

Immunohistochemical study of TAF II 250 in the rat laryngeal nervous system.

TAF II 250 在大鼠喉神经系统中的免疫组织化学研究。

• 发表时间: 2005
• 期刊: Hitol Histopathol 20・4
• 作者: Okano H;et al.
• 通讯作者: et al.