DEVELOPMENT OF COMPUTER-AIDED PRESCRIPTION SYSTEM FOR PERSONALIZED PHARMACOTHERAPY BASED ON THE PHAEMACOKINETICS AND PHARMACODYNAMICS

基于药代动力学和药效学的个体化药物治疗计算机辅助处方系统的开发

• 批准号: 16390043
• 负责人: SAWADA Yasufumi
• 金额: $ 7.87万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390043/
• 关键词: PERSONALIZED MEDICATION; DOSAGE OPTIMIZATION; COMPUTER-AIDED SYSTEM; DRUG INTERACTIONS; PROPER USE OF DRUG; DRUG EVOLUTION; DRUG INFORMATION; 医療品情報; PERSONALIZED MEDICATION; DOSAGE OPTIMIZATION; COMPUTER-AIDED SYSTEM; DRUG INTERACTIONS; PROPER USE OF DRUG; DRUG EVOLUTION; DRUG INFORMATION; 医療品情報

The aim of this study was to develop the computer-aided system that assists dosage regiment optimization, prescription checking, proper use of drugs and distribution of drug information based on the pharmacokinetics and pharmacodynamics. We developed algorithms for personalized pharmacotherapy with regard to 1) dosage adjustment of quinolone antibiotics and angiotensin converting enzyme inhibitors in patients with renal dysfunction, 2) quantitative estimation of time-dependent effects of St.John's wort on the drug metabolism and excretion, 3) receptor occupancy-estimation of antipsychotics-induced adverse reactions, 4) dose regime recommendations to avoid drug interaction between new-quinolones and metal cations, 5) estimation of dosing interval dependency of the interaction between itraconazole and triazolam, 6) assessment of the effects of α1-adorenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory, 7) avoiding piloerection associated with antidepressants, and 8) optimization of the dosage regimen of TS-1 (a combination preparation of tegafur, gimeracil and oteracil potassium). We also developed prototype systems for some of the above algorithms on a personal computer. For example, with regard to the above 1), we developed a computer-aided system that helps to optimize the dosage and dosing time in patients with arbitrary grade of renal function by adjusting the patient's plasma concentration profile to that of subjects with normal renal function.Moreover, we inquired, by pharmacists' questionnaire, the needs for the computer-aided systems for dosage optimization after patients' poor compliance or alteration of the dosage form, and developed the prototypes. We also inquired into the standardization of drug information with regard to the dosage formulation to develop a computer-aided prescription checking system. (260 words)

这项研究的目的是开发计算机辅助系统，该系统有助于剂量团优化，处方检查，适当使用药物以及基于药物治疗和药效学的药物信息分配。我们开发了针对肾功能障碍的患者的奎诺酮抗生素和血管紧张素转化酶抑制剂的剂量调整的个性化药物疗法的算法，2）圣约翰质量的时间依赖性估计对药物代谢和极端反应的时间依赖性，3）受体反应，4）剂量状态建议避免新喹诺酮与金属阳离子之间的药物相互作用，5）估算伊曲康唑和三唑仑之间相互作用的剂量间隔依赖性的估计，6）评估α1-亚种子概感拮抗剂在良性前列腺中的α1-亚种子拮抗剂的影响，基于受体的良性增生剂的良性和4），避免了与受体居住的养老机相关的，避免了8），避免了persive and persightant and persige and pility and pility persige and pil pilters and。 TS-1的方案（Tegafur，Gimeracil和Oteracil Potassium的组合制剂）。我们还为个人计算机上的某些算法开发了原型系统。 For example, with regard to the above 1), we developed a computer-aided system that helps to optimize the dosage and dosing time in patients with arbitrary grade of renal function by adjusting the patient's plasma concentration profile to that of subjects with normal renal function.Moreover, we invited, by pharmacists' questionnaire, the needs for the computer-aided systems for dosage optimization after patients' poor compliance or alteration of the dosage form, and developed the原型。我们还询问了有关剂量配方的药物信息的标准化，以开发计算机辅助处方检查系统。 （260个单词）