Effect of Electrical Stimulation to Motor Disturbance in Central Nerves System.

电刺激对中枢神经系统运动障碍的影响。

• 批准号: 13680946
• 负责人: MURAKAMI Shinji
• 金额: $ 1.92万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680946/
• 关键词: Electrical Stimulation; More Effective Condition; Histological; Type of Muscle Contraction; Type I Muscle fiber; Type II Muscle fiber; 中枢性運動障害; 経皮的電気刺激; 刺激パラメーター; 随意的連続運動; 中枢神経; 痙性障害; 動作解析; 表面筋電図

To investigate theraptic electrical stimulation to motor disturbance in central nervous system, we planed to entry the patients with central nervous system disease, however we found few report to research the effective condition of electrical stimulation to muscle contraction. So, we decided to research the more effective electrical stimulation condition for muscle contraction. If we did not get the more effective condition for electrical stimulation to make muscle contraction, the patients would accept less effective therapy. We started to investigate the more effective condition for electrical stimulation using rat preparation.This research was to determine the morphologic and histologic effects of electrical stimulation(ES) used to prevent muscle atrophy, and to investigate the effects of ES at different stimulation frequencies in preventing atrophy in different muscle fiber types.Research design was that rats in the hindlimb suspended (HS) plus ES group were subjected to 20-and 30-Hz stimulation (ES1, ES2) Every other day for 2wks.In our rerearch, short periods of low-intensity, low-stimulation frequency(20Hz) ES of musele during periods of inactivity could maintain changes in both morphologic and histologic properties of the slow-twitch muscle fibers(soleus). Short periods of low-intensity, high-frequency(30Hz) ES of muscle during periods of inactivity could maintain changes in both morphologic and histologic properties of the fast-twitch muscle fibers (extensor digitorum longus).So, we get the more effective condition for electrical stimulation for muscle contraction and are to prepare clinical research for electrical stimulation to motor disturbance in central nervous system. This research was very important for those electrical stimulation therapy effectively.

为了调查中枢神经系统中对运动障碍的治疗电刺激，我们计划进入患有中枢神经系统疾病的患者，但是很少有报道来研究电刺激对肌肉收缩的有效状况。因此，我们决定研究肌肉收缩的更有效的电刺激条件。如果我们没有获得更有效的电刺激条件以使肌肉收缩，则患者将接受较低的疗效治疗。我们开始使用大鼠制备研究更有效的电刺激条件。这项研究是确定用于防止肌肉萎缩的电刺激（ES）的形态和组织学效应，并研究了在不同刺激频率下ES在防止不同刺激频率下的影响。研究设计是在不同肌肉纤维类型中的萎缩。研究的是悬浮的后肢（HS）加ES组的大鼠每隔一天对2WK进行20和30-Hz刺激（ES1，ES2）。在不活动期间，低强度，低刺激频率（20Hz）ES可以维持慢速肌纤维（Soleus）的形态和组织学特性的变化。在不活动期间，短期低强度，高频（30Hz）肌肉的肌肉可能会保持快速扭曲肌肉纤维的形态和组织学特性的变化（延伸肌longum）。因此，我们得到了更有效的条件为了进行肌肉收缩的电刺激，并准备为中枢神经系统中的运动障碍做好临床研究。这项研究对于那些有效的电刺激疗法非常重要。