Functions of the cortico-subthalamo-pallidal pathway

皮质-下丘脑-苍白球通路的功能

• 批准号: 13680890
• 负责人: NAMBU Atsushi
• 金额: $ 2.3万
• 依托单位: Okazaki National Research Institutes (2002-2003)Tokyo Metropolitan Organization for Medical Research (2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680890/
• 关键词: Basal ganglia; Subthalamic nucleus; Globus pallidus; Hyperdirect pathway; Direct pathway; Indirect pathway; Motor control; Parkinson's disease; 関節路; GABA; グルタミン酸

The functional significance of the cortico-subthalamo-pallidal "hyperdirect" pathway has been investigated, and a dynamic "center-surround model" of basal ganglia function in the control of voluntary limb movements has been suggested. When a voluntary movement is about to be initiated by cortical mechanisms, a corollary signal conveyed through the "hyperdirect" pathway first inhibits large areas of the thalamus and cerebral cortex that are related to both the selected motor program and other competing programs. Then, another corollary signal through the cortico-striato-pallidal "direct" pathway disinhibits their targets and releases only the selected motor program. Based on this model, akinesia observed in Parkinson disease could better be explained by reduced disinhibition in the thalamus and cortex through the "direct" pathway in the spatial and temporal domains. Amelioration of akinesia after subthalamic lesion could also be understood by restored disinhibition in the thalamus and cortex.

已经研究了基底神经节功能在控制自愿肢体运动中的动态“中心旋转模型”的皮质 - 亚甲状腺 - 甲状腺 - 甲状腺 - 甲基甲基甲基甲基甲基 - 甲基甲基“高直接”途径的功能意义。当自愿运动即将通过皮质机制引发时，首先通过“高导向”途径传达的推论信号会抑制与所选运动计划和其他竞争计划相关的丘脑和大脑皮层的大面积。然后，通过Cortico-Striato-Pallidal“ Direct”途径的另一个推论信号diSundibe抑制其目标，并仅释放选定的电动机程序。基于该模型，可以通过空间和时间域中的“直接”途径在帕金森氏病中观察到的智慧。丘脑下腹腔病变后的甲壳虫的改善也可以通过恢复的丘脑和皮质中的抑制作用来理解。

项目成果

Nambu A, Kaneda K, Tokuno H, Takada N: "Organization of corticostriatal motor inputs in monkey putamen."J Neurophysiol. 88. 1830-1842 (2002)

Nambu A、Kaneda K、Tokuno H、Takada N：“猴壳核皮质纹状体运动输入的组织”。《神经生理学杂志》。

Fujiwara-Tsukamoto Y, Isomura Y, Nambu A, Takada M: "Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells."Neuroscience. 119. 265-275 (2003)

Fujiwara-Tsukamoto Y、Isomura Y、Nambu A、Takada M：“兴奋性 GABA 输入直接驱动成熟海马 CA1 锥体细胞中的癫痫样节律同步。”神经科学。

Takada M, Hamada I, Tokuno H, Inase M, Ito Y, Hasegawa N, Ikeuchi Y, Imanishi M, Akazawa T, Hatanaka N, Nambu A: "Corticostriatal projections from the cingulate motor areas in the macaque monkey. The Basal Ganglia VI"Kluwer/Plenum. 685(419-428) (2002)

Takada M、Hamada I、Tokuno H、Inase M、Ito Y、Hasekawa N、Ikeuchi Y、Imanishi M、Akazawa T、Hatanaka N、Nambu A：“猕猴扣带运动区的皮质纹状体投影。基底神经节 VI

Isomura Y, Ito Y, Akazawa T, Nambu A, Takada M: "Neural coding of "attention for action" and "response selection" in primate anterior cingulate Cortex"J Neurosci. 23. 8002-8012 (2003)

Isomura Y、Ito Y、Akazawa T、Nambu A、Takada M：“灵长类动物前扣带皮层“动作注意”和“反应选择”的神经编码”J Neurosci。

Tachibana Y, Nambu A, Hatanaka N, Miyachi S, Takada M: "Input-output organization of the rostral part of the dorsal premotor cortex, with special reference to the corticostriatal projection."Neurosci Res. 48. 45-57 (2004)

Tachibana Y、Nambu A、Hatanaka N、Miyachi S、Takada M：“背侧前运动皮层喙部的输入输出组织，特别是皮质纹状体投射。”Neurosci Res。