The Effects of Laughter and Happy Experiences on Immune Functions and QOL of the Elderly under Treatment

笑声和快乐经历对接受治疗的老年人免疫功能和生活质量的影响

基本信息

批准号：
13672479
负责人：
TANAKA Aiko
金额：
$ 1.6万
依托单位：
Yamaguchi Prefectural University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672479/
关键词：
NK cell Immune function QOL Laughter Rakugo Manzai 音楽カラオケ

项目摘要

The purpose of this study was to clarify what effects laughter and happy experiences could have on the immune functions and QOL of the elderly under treatment. During the first stage, we conducted two experiments : the effects of karaoke [musical experience]. On the immune functions and the effects of watching a video comedy show on the immune functions of female college students, examining changes in the NK cells. The results showed that viewing a comedy show (positive fun) was related to a more significant increase of the NK cells than karaoke (active fun). Based on the results, we conducted the second stage using "live or video presentations of rakugo [comic monologue] and manzai [comic backchat]." We then examined the changes in the immune functions and QOL. The subjects were men and women of 70 years of age or above who were free of senility and staying in therapeutic units. Once a week, rakugo or manzai was presented and this was continued for 4 weeks. Before and after the presentation in the first and the fourth weeks, blood sample was taken and a questionnaire was administered. The first blood samples of 8 persons tested showed a significant increase in the following : NK cell activation (three subjects, 37.5%), the number of NK cells (six, 75%), β -endorphin (six, 75%), ACTH (six, 75%), and cortisol (seven, 87.5%). The last blood samples of 6 persons tested showed a significant increase in the following : NK cell activation (five, 83%), the number of NK cells (three, 50%), β-endorphin (four, 67%), ACTH (three, 50%), and cortisol (three, 50%). On the PGC Morale Scale and the Subjective Happiness Scale, three (50%) persons showed a significant increase over the first measurement. These results indicated that laughter and happy experiences exerted a somewhat positive effect on the immune functions and QOL.

本研究的目的是阐明笑声和快乐体验对接受治疗的老年人的免疫功能和生活质量有何影响。在第一阶段，我们进行了两个实验：卡拉OK（音乐体验）对免疫的影响。研究了观看喜剧视频节目对女大学生免疫功能的影响，检查了 NK 细胞的变化，结果显示，观看喜剧节目（积极的乐趣）与 NK 细胞的增加更为显着。卡拉OK（活跃的乐趣）。根据结果，我们进行了第二阶段，使用“单口相声（单口相声）和漫哉（漫画背聊）的现场或视频演示”，然后我们检查了免疫功能和生活质量的变化。受试者为 70 岁的男性和女性。或以上，无衰老并入住治疗单位，每周进行一次落语或万岁治疗，并持续 4 周，在第一周和第四周进行治疗之前和之后，采集血液样本并进行治疗。对 8 名受试者的第一批血液样本进行了问卷调查，结果显示以下各项显着增加：NK 细胞活化（3 名受试者，37.5%）、NK 细胞数量（6 名，75%）、β-内啡肽（6 名，75%）。 75%）、促肾上腺皮质激素（6 个，75%）和皮质醇（7 个，87.5%） 6 名测试者的最后一次血液样本显示以下各项显着增加： NK 细胞。 PGC 上的激活（5 个，83%）、NK 细胞数量（3 个，50%）、β-内啡肽（4 个，67%）、ACTH（3 个，50%）和皮质醇（3 个，50%）。士气量表和主观幸福感量表中，三人（50%）比第一次测量显着增加。这些结果表明笑声和快乐的经历对免疫功能和生活质量产生了一定的积极影响。