Noninvasive Measurement of Temperature Distribution in Tissues by Ultrasonic CT

超声 CT 无创测量组织温度分布

• 批准号: 13650241
• 负责人: NAWATA Yutaka
• 金额: $ 1.22万
• 依托单位: Yatsushiro National College of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650241/
• 关键词: Ultrasonic Sound; Computed Tomography; Temperature Measurement; Tissue; Sound speed

It is necessary to measure the temperature distributions in tissues during hyperthermia which is a treatment of cancer. We have anticipated a technology measuring indirectly the interior temperature distribution of the arbitrary transverse section in tissues and displaying the image for monitoring.We can obtain the sound speed distribution within the object by measuring the transit time of sound wave with ultrasonic CT. The purpose of this study is to develop a method measuring indirectly the temperature distribution in tissues from the differences in sound speed before and after heating, using the characteristics that sound speed depends on the temperature.The first experiment we made was about the dependence of temperature on sound speed in water, agar and several excised tissues, and we obtained some relations between the temperature and the sound speed.Then, the phantom made of agar was placed in a water bath. A series of sound projections was measured before and after heating by ultrasonic CT method. We obtained the distribution of the temperature differences below 1℃ in phantom by subtracting the sound distribution before heating from after heating.Next, we made the experiment with excised tuna in a water bath. But we were not able to measure the temperature difference below 1℃ in tuna. This is because the difference in sound speed between tuna and water is much more than the difference between agar and water. Tissue has to be placed in liquid which has the sound speed close to the sound speed in tissue in order to obtain the temperature distribution in tissue.We can make the glucose solution having a given sound speed by changing the concentration. We measured the dependence of sound speed in glucose solution on temperature and concentration. Then we made the experiment with excised tuna and glucose solution having the sound speed close to tuna's. As a result, We were able to measure the temperature difference below 1℃ in excised tuna.

在高温期间，有必要测量组织中组织中的温度分布。我们已经预料到了一项技术，可以间接测量组织中任意横截面的内部温度分布并显示用于监视的图像。我们可以通过用超声波CT测量声波的传输时间来获得对象内的声速分布。这项研究的目的是开发一种方法，通过使用声音速度取决于温度的特征来间接地测量组织中的温度分布。我们做出的第一个实验是关于水，琼脂和几个出色的组织的温度依赖温度对温度的依赖性，我们在温度和声音速度之间获得了一定的速度。通过超声CT方法加热之前和之后，测量了一系列声音项目。我们通过在加热后加热前减去声音分布来获得幻影中温度差的分布。下一个，我们在水浴中使用出色的金枪鱼进行了实验。但是我们无法测量金枪鱼中1℃以下的温度差。这是因为金枪鱼和水之间的音速差异远远超过琼脂和水之间的差异。必须将组织放置在液体中，该液体的声速接近组织中的声速，以获得组织中的温度分布。我们可以通过改变浓度来使具有给定声速的葡萄糖溶液。我们测量了葡萄糖溶液中声速对温度和浓度的依赖性。然后，我们使用优秀的金枪鱼和葡萄糖溶液进行了实验，声速靠近金枪鱼。结果，我们能够测量出色的金枪鱼中低于1℃的温度差。

项目成果

縄田 豊, 中村 大治: "超音波CTによる生体内温度分布の非侵襲的測定法に関する研究"第16回バイオエンジニアリング講演会講演論文集. 379-380 (2004)

Yutaka Nawata、Daiji Nakamura：“利用超声波 CT 无创测量体内温度分布的研究”第 16 届生物工程会议论文集 379-380 (2004)。

Measurement of Two-Dimensional Temperature Distribution in Gas by a Resistance Wire CT Method

电阻丝CT法测量气体二维温度分布

• 发表时间: 2002
• 期刊: Research Reports Yatsushiro National College of Technology No.24
• 作者: Yutaka Nawata;Kaoru Furushima;Michiru Miyasaka
• 通讯作者: Michiru Miyasaka

Noninvasive Measurement of Temperature Distribution in Tissues by Ultrasonic CT

超声 CT 无创测量组织温度分布

• 发表时间: 2005
• 期刊: 6^<th> KSME-JSME Thermal & Fluids Engineering Conference
• 作者: Yutaka Nawata;Kaoru Furushima;Tohru Yamashita
• 通讯作者: Tohru Yamashita

縄田 豊, 古嶋 薫, 宮坂 美智留: "抵抗線CT法によるガスの二次元温度分布の測定"八代高専紀要. 第24号. 9-14 (2002)

Yutaka Nawata、Kaoru Koshima、Michiru Miyasaka：“利用电阻丝 CT 法测量气体的二维温度分布”八代工业大学公报第 24 期 9-14（2002 年）。

Measurement of Temperature Distribution in Excised Tissues by an Ultrasonic CT

超声 CT 测量切除组织中的温度分布

• 发表时间: 2004
• 期刊: Proceedings of the 16th Bioengineering Conference, 2003 Annual Meeting of BE/JSME
• 作者: Yutaka Nawata;Taiji Nakamura
• 通讯作者: Taiji Nakamura