Molecular devices by functionalization of modified DNA

通过修饰 DNA 功能化的分子装置

基本信息

批准号：
13305058
负责人：
MAJIMA Tetsuro
金额：
$ 35.53万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13305058/
关键词：
DNA DNA molecular wire Modified DNA Functionalization of DNA Molecular device Nucleic acid Hole transfer Laser photolysis パルスラジオリシス

项目摘要

In this research, it is aimed that various functionalities are given to modification DNA by using DNA modified covalently with various functional chromophores, controlling the functionalities can be established, and the possibility of modified DNA as molecular devices in the living body system is clarified. Especially, in order to clarify the hole transfer in DNA with respect to the construction of DNA molecular wire, photofunctions of modified DNA having photofunctional chromophores has been studied in the nano meter scale depending on the nuclear base sequences. Not only one chromophore but also several chromophores are modified on one DNA in order to clarify the charge separation, hole migration, and charge recombinataion in the nano meter scale and in the nano-pico second time scale. Technology that accurately operates functional molecule by means of molecular assembly is necessary to the nanotechnology of a bottom-up type, and it is necessary to establish the method of molecular assembly according to artificial information. DNA is the most powerful molecule where an accurate molecular assembly is achieved with many kinds of molecules and has the advantage that a variety of functional molecules can be introduced by the chemical modification in DNA. Therefore, DNA unit with the branch dividing structure was synthesized to construct a regular and rigid DNA structures based on self-assembly, and we succeeded to construct DNA nano structure to use this constructing a bridge DNA. In order to establish molecular devices by functionalization of modified DNA more precisely, to achieve the multifunction like the chlorophyll, photofunction, and complex functions is very important. It is also necessary to clarify the method of construction of modified DNA with a high performance and molecular device as a biomolecular function, and to develop the possibility of modified DNA as molecular devices in the living body system.

在这项研究中，目的是通过使用各种功能性发色团共价修改DNA来对DNA进行各种功能，可以建立控制功能，并且可以阐明修饰DNA作为生物体系中的分子设备的可能性。尤其是，为了阐明DNA中DNA中的孔转移，根据核碱基序列，已经研究了具有光功能性发色团的修饰DNA的光功能。不仅在一个DNA上修改了一个发色团，而且还对几个发色团进行了修饰，以阐明纳米表尺度和纳米PICO的第二个时间尺度的电荷分离，孔迁移和电荷重组。对于自下而上类型的纳米技术是必要的，可以通过分子组装精确运行功能分子的技术，必须根据人工信息来建立分子组装的方法。 DNA是最强大的分子，其中通过多种分子实现精确的分子组件，并且具有DNA中化学修饰可以引入各种功能分子的优势。因此，合成具有分支分裂结构的DNA单位，以基于自组装的形式构建规则且刚性的DNA结构，我们成功地构建了DNA纳米结构以使用该构建桥接DNA的情况。为了通过更精确地通过修饰DNA的官能化来建立分子设备，以实现多功能，例如叶绿素，光功能和复杂功能非常重要。还必须阐明用高性能和分子装置作为生物分子功能构建修饰的DNA的方法，并开发出修改的DNA作为活体系统中分子装置的可能性。

项目成果

期刊论文数量（256）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

On the Electronic Character of Localized Singlet 2,2-Dimethoxycyclopentanc-1,3-diyl Diradicals : Substituent Effects on the Lifetime

定域单线态2,2-二甲氧基环戊烷-1,3-二基双自由基的电子特性：取代基对寿命的影响

DOI：
发表时间：
2002
期刊：
J.Am.Chem.Soc.(Commun.) 124, 23
影响因子：
0
作者：
Kiyohiko Kawai;Kiyohiko Kawai;Kiyohiko Kawai;Xichen Cai;Kiyohiko Kawai;Manabu Abe
通讯作者：
Manabu Abe

A.Ouchi: "A Two-Color Laser Photolysis Methods for Determining Reaction Rates of Short-Lived Intermediates by Product Analysis : Applictaion to the o-inodimethane Problem"J.Am.Chem.Soc.. 125・4. 1104-1108 (2003)

A.Ouchi：“通过产物分析确定短寿命中间体反应速率的双色激光光解方法：在邻二甲烷问题中的应用”J.Am.Chem.Soc.. 125・4。 2003）