RELATIONSHIP BETWEEN STATE OF TRNAMUCOSAL GAS EXCHANGE AND

粘膜气体交换状态与

• 批准号: 12671683
• 负责人: AOKI Kazuhiro
• 金额: $ 1.86万
• 依托单位: JIKEI UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671683/
• 关键词: BLOOD VOLUME OF TISSUE; BLOOD FLOW; MUCOSAL LESION; TRANSMUCOSAL GAS EXCHANGE; TOTAL MIDDLE EAR PRESSURE; CARBON DIOXTDR; OXYGEN; MIDDLE EAR INFLAMMATORY CONDTTION; 血瘤速度; 耳粘膜病変

We reported that the transmucosal gas exchange function existed in the middle ear cavity and this function was effected by the seventy of middle ear mucosal lesions, employing children with otitis media with efiusion (OME) to whom we had inserted a tympanic ventilation tube (TUBE), and this function was recovered by the treatment of OME. Tb elucidate what causes changes in the transmucosal gas exchange function, normal adults New Zealand White rabbits were used to investigate the change in the middle ear total pressure (METP), the blood flow and the histopathological change in the mucous membrane. The present experiments in rabbits have shown that the METP is a result of gas exchange between the middle ear cavity and the mucosal vessels and the METP depend on the degree of blood flow in the vessels. Also this blood flow is related to the degree of inflammatory change of mucosa. In our clinical study, when the mucosaj is inflamed, the transmucosal gas exchange function is severely disrupted, while the incidence of recurrence of otitis media is increased in patients with a low METP at the time of removal of TUBE.Based on these facts, it can be concluded that changes m the METP reflect the state of the middle ear mucosa and thus represent important diagnostic information for use in the treatment of patients with OME.

我们报告了中耳腔存在跨粘膜气体交换功能，并且该功能受到70个中耳粘膜病变的影响，采用了渗出性中耳炎（OME）儿童，我们对其插入了鼓室通气管（TUBE） ，并且通过OME治疗该功能得以恢复。为了阐明跨粘膜气体交换功能变化的原因，使用正常成年新西兰白兔来研究中耳总压（METP）、血流和粘膜组织病理学变化。目前对兔子的实验表明，METP是中耳腔与粘膜血管之间气体交换的结果，并且METP取决于血管中血流的程度。而且这种血流量与粘膜炎症改变的程度有关。在我们的临床研究中，当粘膜发炎时，跨粘膜气体交换功能会受到严重破坏，而拔除TUBE时METP较低的患者中耳炎复发的发生率会增加。基于这些事实，可以得出结论，METP 的变化反映了中耳粘膜的状态，因此代表了用于治疗 OME 患者的重要诊断信息。

项目成果

Tsuji Tbmihiko: "Pathogenesis of adhesive tympanum-Mucosal function in the middle ear pneumatic space-"Oto-Rhino-Laryngo logy. 44. 6-8 (2001)

Tsuji Tbmihiko：“鼓室粘连的发病机制-中耳气动间隙的粘膜功能-”耳犀喉学。

青木和博: "中耳炎と乳突蜂巣発育"JOHNS. 19-1. 98-101 (2003)

Kazuhiro Aoki：“中耳炎和乳突蜂窝状发育”JOHNS 98-101 (2003)。

辻 富彦: "鼓膜癒着症の成因に関する研究"耳鼻咽喉科展望. 44-5. 6-8 (2001)

Tomihiko Tsuji：“鼓膜粘连的原因研究”《耳鼻喉科展望》44-5（2001）。

辻 富彦: "鼓膜癒着症の成因に関する研究"耳鼻咽喉科展望. 44-5. 326-344 (2001)

Tomihiko Tsuji：“鼓膜粘连的原因研究”《耳鼻喉科展望》44-5（2001）。

Aoki Kazuhiro: "Paracentesis and insertion of tympanic ventilation tube"Otolaiyngology-Head and Neck Surgery. 74. 15-19 (2002)

青木和宏：“穿刺术和鼓室通气管插入”耳鼻喉科-头颈外科。