The Protective Effect of Partial Liquid Ventilation on Mechanical Ventilation Induced Lung Injury

部分液体通气对机械通气所致肺损伤的保护作用

• 批准号: 12671455
• 负责人: UCHIDA Tokujiro
• 金额: $ 2.3万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671455/
• 关键词: Mechanical ventilation; Partial liquid ventilation; Lung injury; パーフルオロカーボン

1. Analysis of respiratory mechanics by magnetic resonance imaging :We investigated the relationship between the airway pressure and the distribution of inspiratory gas during partial liquid ventilation using magnetic resonance imaging technique. Partial liquid ventilation partially ameliorated distribution of inspiratory gas, although the alveoli in the dependent region were not completely aereated in severe lung injury.2. Partial liquid ventilation partially improved alveolar fluid clearance after mechanical ventilation induced lung injury :Protective effect of partial liquid ventilation on alveolar fluid clearance was investigated using rat mechanical ventilation induced lung injury model. In lung injury group (n=12), alveolar fluid clearance was significanltly decreased from those from control group(n=12). Partial liquid ventilqtion partially improved alveolar fluid clearance.3. Partial liquid ventilation did not improved cytokine production in injured lung :We also measured TNF-a, IL1-b, IL6 level in the lung homogenate after the experiment of alveolar fluid clearance. But there were no difference in these cytokine level between the lung injury animal and those ventilated with partial liquid ventilation.In conclusion, partial liquid ventilation partially ameliorated.

1.磁共振成像呼吸力学分析：我们利用磁共振成像技术研究了部分液体通气时气道压力与吸入气体分布的关系。部分液体通气可部分改善吸气气体分布，但严重肺损伤时依赖区肺泡通气不完全。 2．部分液体通气部分改善机械通气引起的肺损伤后肺泡液清除率：利用大鼠机械通气引起的肺损伤模型研究部分液体通气对肺泡液清除率的保护作用。肺损伤组(n=12)肺泡液清除率较对照组(n=12)显着降低。部分液体通气部分改善肺泡液清除率。3．部分液体通气并没有改善受损肺中细胞因子的产生：在肺泡液清除实验后，我们还测量了肺匀浆中的TNF-a、IL1-b、IL6水平。但肺损伤动物与部分液体通气动物之间这些细胞因子水平没有差异。综上所述，部分液体通气有部分改善。

项目成果

Uchida T.: "Relationship between airway pressure and the distribution of gas-liquid interface, during partial liquid ventilation in the oleic acid lung injury model"Crit Care Med.. 28・8. 2904-2908 (2000)

内田T.：“油酸肺损伤模型中部分液体通气时气道压力与气液界面分布的关系”Crit Care Med.28・8（2000）

Uchida T.: "Relationship between airway pressure and the distribution of gas-liquid interface, during partial liquid ventilation in the oleic acid lung injury model"Crit Care Med.. 28(8). 2904-2908 (2000)

Uchida T.：“油酸肺损伤模型中部分液体通气期间气道压力与气液界面分布之间的关系”Crit Care Med. 28(8)。

Matthay MA,: "Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome"Curr Treat Options Cardiovasc Med.. 4. 139-149 (2002)

Matthay MA，：“临床急性肺损伤和急性呼吸窘迫综合征”Curr Treat Options Cardiovasc Med.. 4. 139-149 (2002)

Uchida T: "Relationship between airway pressure and the distribution of gas-liquid interface_during_partial liquid ventilation in the oleic acid lung injury"Crit Care Med.. 28(8). 2904-2908 (2000)

Uchida T：“油酸肺损伤中气道压力与气液界面分布_期间_部分液体通气之间的关系”Crit Care Med. 28（8）。

Uchida T.: "Inhaled nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions"Intensive Care Med.. 26(6). 764-769 (2000)

Uchida T.：“部分液体通气期间吸入一氧化氮将肺血流转移到非依赖性肺区域”重症监护医学.. 26(6)。