Effect of level of consciousness on blood flow and oxygen consumption in the primary sensory area during sensory stimulation

感觉刺激时意识水平对初级感觉区血流量和耗氧量的影响

• 批准号: 12670870
• 负责人: TANAKA Hisashi
• 金额: $ 1.73万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670870/
• 关键词: functional magnetic resonance imaging; transverse temporal gyrus; sleep; functional MRI; 眠睡; 脳血流量; 聴覚刺激

We investigated how brain responded to auditory stimuli during wakefulness and sleep. First, we explored the methods to obtain electroencephalogram (ECG) in magnetic resonance (MR) imaging system. Although pulse artifact migrated, ECG which could be used to detect sleep stages was obtained. After preliminary experiments, we measured signal change with functional magnetic resonance imaging in six sleep deprived male volunteers. They ranged in age between 25 to 44 years. None of them had sleep, hearing, or neurological problems. After applying electrodes, they laid supine with headphones for auditory stimulation. Measurement was performed with 1.5-T MR system. MR image acquisition was performed ever 12 seconds. Auditory stimulus was alternated every 36 seconds. Region of interest was set to be bilateral transverse gyri, in which primary auditory cortex exists. Results showed that percentage signal change, the number of activated pixels, and the maximal Z-score during sleep were significantly less than those during wakefulness.

我们调查了在清醒和睡眠期间大脑如何应对听觉刺激。首先，我们探索了在磁共振（MR）成像系统中获得脑电图（ECG）的方法。尽管脉搏伪像迁移，但可用于检测睡眠阶段的ECG。初步实验后，我们通过六个睡眠剥夺的男性志愿者的功能磁共振成像来测量信号变化。他们的年龄在25至44岁之间。他们都没有睡觉，听力或神经系统问题。施加电极后，他们仰卧给耳机以进行听觉刺激。用1.5-T MR系统进行测量。 MR图像采集进行了12秒。听觉刺激每36秒交替一次。感兴趣的区域设置为双侧横向回旋，其中主要听觉皮层存在。结果表明，信号变化百分比，活化像素的数量和睡眠期间的最大Z分数明显小于清醒期间的Z分数。