Mechanisms of Itch

瘙痒的机制

• 批准号: 12670838
• 负责人: TAKAMORI Kenji
• 金额: $ 1.54万
• 依托单位: JUNTENDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670838/
• 关键词: itch; mechanism of itch; nerve fiber; C fiber; opioid peptide; opioid receptor; μ-receptor; κ-receptor; かゆみ; ドライスキン; アトピー性皮膚炎; 表皮内神経線維; C線維; セマフォリン; 老人性皮膚掻痒症; NGF; neurotrophic factor

Itch is classified into 2 types such as peripheral itch and central itch. Peripheral itch is caused by the activation of nerve C fibers which is distributed in the dermoepidermal junction, while central itch is caused by the activation of opioid peptide-opiold receptor system. Clinically itch is grouped by itch which shows effectiveness to antihistamine drugs and itch shows resistance to antihistamine drugs. In this research, we investigated the mechanisms of itch of xerosis, atopic dermatitis and hemodialysis patients which shows resistance to antihistamine drugs. 1)nerve C fibers which penetrated into the subcomear area are activated directly by the outer stimulants such as mechanical, chemical and thermal stimulations in dry skin of zerosis and atopic dermatitis, resulted in itching. 2)In patients with hemodialysis, ti -opioid system indtices itching is superior to ii -opioid system suppress itching. Agonist of κ-opioid receptor suppressed itching of patients with hemodialysis.These findings suggest that agonist of κ-opioid receptor suppress the itching shows resistance against antihistamine drugs.

瘙痒分为两种类型，例如外围瘙痒和中心瘙痒。抗组织药物涉及对抗组胺药物的抗性抗性药物的机制，其抗性药物的耐药性。在血液透析的患者中，瘙痒2）ti -Apioid System瘙痒是抑制瘙痒的瘙痒性的TOII -Opioid System抑制瘙痒。

项目成果

高森 建二: "かゆみと疾患"最新皮膚科学大系. 3. 128-132 (2002)

Kenji Takamori：“瘙痒与疾病”最新皮肤病学。 3. 128-132 (2002)

高森建二: "最新アトピー性皮膚炎診療マニュアル-かゆみ対策"Monthly Book Derma. 54. 54-59 (2001)

Kenji Takamori：《最新特应性皮炎治疗手册-瘙痒对策》月刊 Derma 54. 54-59 (2001)

高森 建二: "オピオイドペプチドを標的とした痒みの治療"臨床皮膚科. 56. 145-147 (2002)

Kenji Takamori：“针对阿片肽的瘙痒治疗”《临床皮肤病学》56. 145-147 (2002)。

高森建二: "ドライスキンによる痒みのメカニズム"臨床皮膚科. 54. 52-56 (2000)

Kenji Takamori：“皮肤干燥引起瘙痒的机制”《临床皮肤病学》54. 52-56 (2000)。

高森 建二: "かゆみ対策"MB Derma. 54. 54-59 (2001)

Kenji Takamori：“瘙痒对策”MB Derma 54. 54-59 (2001)