Protein-Hydroxyapatite Hybrid Coating on Titatium Substrate by the Sol-Gel Process

通过溶胶-凝胶法在钛基底上形成蛋白质-羟基磷灰石杂化涂层

• 批准号: 12650706
• 负责人: HIRAI Shinji
• 金额: $ 2.3万
• 依托单位: Muroran Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650706/
• 关键词: Hybrid Coating; Sol-Gel Process; Collagen; Silk Fibroin; Amorphous Hydroxyapatite; Polyvinilpyrrolidone; UV Irradiation; Titanium; チタン; ゾル-ゲル法; 絹フィブロイン; 細胞付着試験; 擬似体液浸漬; ゾルーゲル法; 絹; 水酸アパタイト; チタン基板; 細胞活性; 疑似体液浸漬実験

To improve the bone formation, the hybrid coating in which the collagen or silk fibroin dispersed in the organically modified amorphous hydroxyapatite using polyvinilpyrrolidone were prepared by a sol-gel process combined with UV irradiation at ambient temperature after dipping /withdrawing a substrate into/from the sol. When the coating was modified by polyvinilpyrrolidone, the elastic modulus of coating increased with increasing its content, and an adhesion of coating was consequently improved. SEM observation indicated that some crystallites of hydroxyapatite were deposited after slight three days of immersion in simulated body fluid, whereas no change was observed on the surface of titanium substrate and original hydroxyapatite coating.

为了改善骨形成，杂化涂料在其中，胶原蛋白或丝纤维蛋白分散在有机修饰的非晶羟基磷灰石中，使用聚乙烯基吡咯烷酮通过溶胶 - 凝胶工艺与紫外线辐照在环境温度下浸入 /降级 /撤离A siptrate后，通过sol-gel工艺与紫外线辐照相结合，制备。 sol。当涂层通过聚二吡咯烷酮修饰时，涂层的弹性模量随着其含量的增加而增加，因此涂层的粘附力得到了改善。 SEM观察表明，在浸入模拟的体液中三天后沉积了一些羟基磷灰石的微晶，而在钛底物和原始羟基磷灰石涂层的表面没有观察到任何变化。

项目成果

K.Watanabe,M.Sakairi,H.Takahashi,K.Takahiro,S.Nagata and S.Hirai: "Formation of Composite Oxide Films on Aluminum by Sol-Gel Coating and Anodizing-For the Development of High Performance Aluminum Electrolytic Capacitors-"J.Electochem.Soc.. (掲載決定).

K. Watanabe、M. Sakairi、H. Takahashi、K. Takahiro、S. Nagata 和 S. Hirai：“通过溶胶凝胶涂层和阳极氧化在铝上形成复合氧化膜 - 用于高性能铝电解电容器的开发 - “J.Electochem.Soc..（已决定出版）。

K.Watanabe, M.Sakairi, H.Takahashi, K.Takahiro, S.Nagata and S.Hirai: "Anodizing of Aluminum Coated with Silicon Oxide by a Sol-Gel Coating"J.Electrochemical Soc.. 148・11. B473-B481 (2001)

K.Watanabe、M.Sakairi、H.Takahashi、K.Takahiro、S.Nagata 和 S.Hirai：“通过溶胶-凝胶涂层对涂覆有二氧化硅的铝进行阳极氧化”J.Electrochemical Soc.. 148・11。 -B481 (2001)

K. Watanabe, M. Sakairi, H. Takahashi, K. Takahiro, S. Nagata, S. Hirai: "Formation of Composite Oxide Films on Aluminum by Sol-Gel Coating and Anodizing - For the Development of High Performance Aluminum Electrolytic Capacitors -"Proc. ECS & ISE Joint In

K. Watanabe、M. Sakairi、H. Takahashi、K. Takahiro、S. Nagata、S. Hirai：“通过溶胶凝胶涂层和阳极氧化在铝上形成复合氧化膜 - 用于高性能铝电解电容器的开发 -

S.Hirai, K.Shimakage, K.Wada: "Chemical Corrosion Resistance Coating on Aluminum Substrates by the Sol-Gel Process"Proc. 2nd Int. Conf. on Processing Materials for Properties. 939-944 (2000)

S.Hirai、K.Shimakage、K.Wada：“通过溶胶-凝胶工艺在铝基板上形成耐化学腐蚀涂层”Proc。

K. Watanabe, M. Sakairi, H. Takahashi, K. Takahiro, S. Nagata, S. Hirai: "Anodizing of Aluminum Coated with Silicon Oxide by Sol-Gel Coating"J. Electrochemical. Soc.. 148-11. B473-B481 (2001)

K. Watanabe，M. Sakairi，H. Takahashi，K. Takahiro，S. Nagata，S. Hirai：“通过溶胶-凝胶涂层对涂覆有二氧化硅的铝进行阳极氧化”J。