Computational study of rupture of the cerebral aneurysms

脑动脉瘤破裂的计算研究

基本信息

批准号：
12650155
负责人：
OSHIMA Marie
金额：
$ 2.24万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650155/
关键词：
Computational Hemodynamics Unrupture Cerebral Aneurysm Medical Image-Based Simulation Blood Flow-Arterial Wall Interaction 3-D Vascular Modeling Multivariate Analysis Database System Evidence-Based Medicine 未破裂脳動脈瘤 FEM 医用画像血流-血管壁の連成

项目摘要

A main cause of subarachnoidal hemorrhages is rupture of a cerebral aneurysm. Once the subarachnoidal hemorrhage occurs, there is a high risk of death. When the cerebral aneurysm is found, it is usually operated because its rupture can not be predicted under the present circumstance. However, an operation of the cerebral aneurysm is difficult and gives not only physical but also financial burdens to a patient. Thus it is quite important to predict a risk factor of individual aneurysm's rupture in order to prevent unnecessary surgeries.The research aims to investigate the relationship between cerebrovascular geometry and hemodynamics in order to predict rupture and creation of cerebral aneurysms. The investigators of the project have been developing a numerical simulation system, which consists of medical image-based geometric modeling, grid generation, finite element fluid simulation, and scientific visualization. A database system is designed so as to organize and analyze medical imag … More es, physiological, and computer graphics or movies of numerical results for the purpose of evidence-based medicine. In addition, since the simulation system assumes the arterial walls as rigid walls, numerical methods are investigated for an effective way to treat blood flow-arterial wall interaction problems.The present research project focuses on the following three topics : 1) Development of medical image-based simulation and database system 2) Numerical simulation of blood flow-arterial wall interaction 3) Comparison of numerical results with clinical dataAs for the topics 1), a total of 19 cases of numerical simulations are conducted for the middle cerebral artery (MCA) junction. The database system was constructed using vascular geometric parameters, and the multivariate analysis is performed using the results of 19cases to estimate a maximum wall shear stress. The results are compared and show good agreement with those of numerical analysis. It is found that diameter of the MCA, ratio of diameter of branching to that of the MCA, and difurcation angle between the MCA and brunching arteries are important geometric factors in determining maximum wall shear stresses. As for the topics 2), a numerical mothod for interaction between blood flow and arterial wall is developed. The method was applied to the curved pipe model and the Intermal Carotid artery model. As a result, it is found that effects of elastic arterial wall on the wall shear distribution is significant despite a small deformation of the arterial wall. Finally, for the topics 3), the survey had been conducted for 20 years at Teikyo University, and the results were summarized to study the relationship between unrupture aneurysms and subarachnoidal homerrhages. Less

蛛网膜下腔出血的主要原因是脑动脉瘤的破裂。一旦蛛网膜下腔出血发生，死亡的风险很高。当发现脑动脉瘤时，通常是因为在当前情况下无法预测其破裂。但是，脑动脉瘤的操作很困难，不仅可以给患者提供身体上的燃烧，还可以给予金融燃烧。为了防止不必要的手术，预测单个动脉瘤破裂的危险因素非常重要。该研究旨在研究脑血管几何形状和血液动力学之间的关系，以预测脑动脉瘤的破裂和创造。该项目的研究人员一直在开发一个数值模拟系统，该系统由基于医学图像的几何建模，网格产生，有限元流体模拟和科学可视化组成。设计数据库系统是为了组织和分析医学图像……更多的ES，物理和计算机图形或数值结果的电影，以循证医学的目的。此外，由于模拟系统将动脉壁假定为刚性壁，因此研究了一种有效的方法来治疗血液流动墙相互作用问题。当前的研究项目侧重于以下三个主题：1）开发基于医学图像的模拟和数据库系统2）与流动壁相互作用的数值模拟的数字相互作用的数值图1）数字的数字构成数字的数字图案。对中大脑中动脉（MCA）结进行了数值模拟。使用血管几何参数构建数据库系统，并使用19个病例的结果进行多变量分析以估计最大壁剪应力。比较结果并与数值分析的结果表现出良好的一致性。发现MCA的直径，分支与MCA的直径比，MCA和早午餐动脉之间的差异是确定最大壁剪应力的重要几何因素。至于主题2），开发了血流与动脉壁之间相互作用的数值基序。该方法应用于弯曲管模型和颈间动脉模型。结果，发现弹性动脉壁对壁剪切分布的影响是重要的目的地。最后，对于主题3），该调查已经在Teikyo University进行了20年，并总结了结果以研究不爆炸动脉瘤和蛛网膜下腔垒手之间的关系。较少的