Combinatorial Molecular Imprinting for the Preparation of Synthetic Polymers Capable of Molecular Recogniti

组合分子印迹制备具有分子识别能力的合成聚合物

• 批准号: 11672151
• 负责人: TAKEUCHI Toshifumi
• 金额: $ 1.98万
• 依托单位: Hiroshima City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11672151/
• 关键词: Molecular Imprinting; Molecular recognition; Combinatorial Chemistry; 蛍光検出; マイクロプレート; コンビナトリアルMI法

In this study, an automated system for molecularly imprinted polymer synthesis and evaluation was examined. In 1999, molecular imprinting for atrazine and ametryn was performed as an example with the use of various concentration of methacrylic acid and 2-(trifluoromethyl) acrylic acid as functional monomers. It appeared that methacrylic acid was suitable for atrazine imprinting and for ametryn imprinting 2-(trifluoromethyl) acrylic acid gave a better selectivity. These results were consistent with the previously reported results of conventional preparation methods, suggesting that the proposed combinatorial molecular imprinting would be feasible for the development of molecularly imprinted polymers. In 2000, a micro titer plate- based method was developed in combinatorial molecular imprinting. By using this method, the evaluation time was extremely shortened and the combinatorial approach became to be more feasible.

在这项研究中，检查了一种用于分子印迹聚合物合成和评估的自动化系统。 1999年，以使用各种浓度的甲基丙烯酸酸和2-（三氟甲基）丙烯酸为功能单体的分子印迹作为抗苯胺和ametryn。似乎甲基丙烯酸适用于阿atrazine烙印，并且用于2-（三氟甲基）丙烯酸的氨基苯丙烯酸具有更好的选择性。这些结果与先前报道的常规制备方法的结果一致，这表明所提出的组合分子印迹对于分子印刷聚合物的发展是可行的。在2000年，在组合分子印记中开发了一种基于微滴板的方法。通过使用此方法，评估时间非常缩短，组合方法变得更可行。

项目成果

Takeuchi,T.,Matsui,J.: "Miniaturized Molecularly Imprinted Continuous Polymer Rods"Journal of High Resolution Chromatography. 23. 44-46. (2000)

Takeuchi,T.,Matsui,J.：“小型化分子印迹连续聚合物棒”高分辨率色谱杂志。

Takeuchi, T., Matsui, J.: "Miniaturized Molecularly Imprinted Continuous Polymer Rods"J.High Resolution Chromatogr.. 23. 44-46 (2000)

Takeuchi, T., Matsui, J.：“小型化分子印迹连续聚合物棒”J.高分辨率色谱. 23. 44-46 (2000)

Matsui, J., Higashi, M., Takeuchi, T.: "Molecularly Imprinted Polymer as 9-Ethyladenine Receptor Having a Porphyrin-based Recognition Center"J.Am.Chem.Soc.. 122. 5218-5219 (2000)

Matsui, J.、Higashi, M.、Takeuchi, T.：“具有基于卟啉的识别中心的作为 9-乙腺嘌呤受体的分子印迹聚合物”J.Am.Chem.Soc.. 122. 5218-5219 (2000)

Takeuchi,T.,Fukuma,D.,Matsui,J.: "Combinatorial Molecular Imprinting : An Approach to Synthetic Polymer Receptors"Analytical Chemistry. 71. 285-290. (1999)

Takeuchi,T.、Fukuma,D.、Matsui,J.：“组合分子印迹：合成聚合物受体的方法”分析化学。

Matsui, J., Kubo, H., Takeuchi, T.: "Molecularly Imprinted Fluorescent-Shift Receptors Prepared Using 2-(Trifluoromethyl) acrylic Acid"Anal.Chem.. 72. 3286-3290 (2000)

Matsui, J.、Kubo, H.、Takeuchi, T.：“使用 2-(三氟甲基)丙烯酸制备的分子印迹荧光位移受体”Anal.Chem.. 72. 3286-3290 (2000)