Studies on the mechanisms of sensory retinal adhesion, its breakdown and reconstruction

感觉性视网膜粘连及其破坏与重建机制的研究

• 批准号: 11671746
• 负责人: NEGI Akira
• 金额: $ 1.02万
• 依托单位: Kobe University (2000-2001)Kumamoto University (1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671746/
• 关键词: RETINA; VITREOUS; MACULA; MACULAR HOLE; RETINAL DETACHMENT; INTERNAL LIMITTING MEMBRANE; VISUAL FIELD DEFECT; 視野狭窄; 人工的後部硝子体剥離; 硝子体手術; 液空気置換; 実験的網膜剥離

We studied the result s of vitrectomy for consecutive 110 eyes with idiopathic macular hole. Closure of hole was achieved in 90%. In experimental retinal hohe of rabbits eyes, early attachment of sensory retina and RPE was essential for closure, and glial and RPE cells played an important roles. Eighteen eyes showed visual field defects, which was always located contralateral to the infusion cannula. The incidence of this visual field defect was influenced strongly by the infusion air pressure. The retinal damage by air pressure was evaluated in rabbit eyes. Sharply demarcated retinal lesions were observed at the opposite side from the infusion cannula with SEM. The internal limitimg membrane was often detached, and the underlying nerve fiber layer was exposed. We concluded the cause of visual field defect was mechanical retinal damage by infusion air pressure. The fundus changes were progressive, so it is important to examine eyes with visual field defect for a follow-up period of several years.

我们研究了连续110只眼特发性黄斑裂孔的玻璃体切除术的结果。孔洞闭合率达90%。在实验性兔眼视网膜中，感觉视网膜和RPE的早期附着对于闭合至关重要，胶质细胞和RPE细胞发挥了重要作用。十八只眼睛出现视野缺损，且始终位于输注插管的对侧。这种视野缺损的发生率很大程度上受输注气压的影响。在兔眼中评估气压造成的视网膜损伤。用扫描电镜在输注套管的另一侧观察到边界清晰的视网膜病变。内界膜常脱落，下面的神经纤维层暴露。我们得出结论，视野缺损的原因是输注气压造成的机械性视网膜损伤。眼底变化是进行性的，因此在几年的随访期内检查视野缺损的眼睛非常重要。

项目成果

HASUHURA T: "Retinal damage by air infusion during vitrectomy in rabbit eye."Invest Ophthlalmol Vis Sci. 41・13. 4300-4304 (2000)

HASUHURA T：“兔眼玻璃体切除术中空气注入造成的视网膜损伤”，Invest Ophthlalmol Vis Sci 41・13（2000）。

T.Hasumura,N.Yonemura,A.Hirata,Y.Murata,A.Negi: "Retinal damage by fluid-air exchage during vitreous surgery in rabbits"Investigative Ophthalmology & Visual Science. 40・4. S943 (1999)

T. Hasumura、N. Yonemura、A. Hirata、Y. Murata、A. Negi：“兔子玻璃体手术期间液体-空气交换造成的视网膜损伤”调查眼科与视觉科学 40・4。

Yamana T: "The processs of closure of experimental retinal holes in rabbit eyes"Graefe's Arch Clin Exp Ophthalmol. 238. 81-87 (2000)

Yamana T：“兔眼实验性视网膜孔的闭合过程”Graefes Arch Clin Exp Ophamol。

Hasumura T: "Retinal damage by air infusion during vitrectomy in rabbit eyes"Invest Ophthalmol Vis Sci. 41. 4300-4304 (2000)

Hasumura T：“兔眼玻璃体切除术中空气注入造成的视网膜损伤”Invest Ophasemol Vis Sci。

Yonemura N: "Fundus changes corresponding to visual field defects after vitrectomy for macular hole"Ophthalmology. 108. 1638-1643 (2001)

米村 N：“黄斑裂孔玻璃体切除术后与视野缺损相对应的眼底变化”眼科。