Clinical and Immuno-histological Study on Desructive Spondyloarthropathy in Paitents Treated with Long-Term Hemodialysis

长期血液透析患者破坏性脊柱关节病的临床和免疫组织学研究

• 批准号: 11671410
• 负责人: ITO Manabu
• 金额: $ 1.79万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671410/
• 关键词: Hemodialysis; Destructive Spondyloarthropathy; Immunology; Histology; Surgical Treatment

This study clarified the mechanisms of severe destructive changes in the spinal components in patients treated with long-term hemodialysis. Distribution of amyloid deposition and destruction of facet joints and disc-body unit were manifested through this project. At site of severe body destruction in vertebral bodies, the activity of osteoclasts was enhanced and that of osteoblasts was completely suppressed. This local pathology played an important role in establishment of server spinal destructive changes. The ideal spinal reconstruction procedures were proposed and the clinical outcomes in cervical reconstruction were published in the international journal of Spine. The results of this strudy were accepted for presentation in many international meetings or symposiums. Spinal fusion rate and surgery success rates were dramatically improved by our invented surgical procedures. This study had a great contribution for the establishment of secure spinal reconstruction surgery for the patients suffering destructive spondyloarhtropathy associated with long-term hemodialysis.

这项研究阐明了长期血液透析患者的脊柱成分严重破坏性变化的机制。该项目表现出淀粉样蛋白沉积的分布和片段关节和圆盘单位的破坏。在椎体严重的身体破坏部位，破骨细胞的活性得到了增强，成骨细胞的活性得到了完全抑制。这种局部病理在建立服务器脊柱破坏性变化方面发挥了重要作用。提出了理想的脊柱重建程序，并在《国际脊柱杂志》上发表了宫颈重建中的临床结果。在许多国际会议或研讨会上，接受了这种努力的结果。我们发明的手术程序可大大提高脊柱融合率和手术成功率。这项研究为建立与长期血液透析相关的破坏性脊椎恐怖症的患者建立安全的脊柱重建手术做出了巨大贡献。

项目成果

Kuniyoshi Abumi, Nanabu Ito, Kiyoshi Kaneda: "Surgical treatment of cervical destructive spondyloarthropathy"Spine. Vol.25, No.22. 2899-2905 (2000)

Kuniyoshi Abumi、Nanabu Ito、Kiyoshi Kaneda：“颈椎破坏性脊柱关节病的手术治疗”脊柱。

Manabu Ito, Kuniyoshi Abumi, Kiyoshi Kaneda, Kyoichi Hasegawa, Takehiro Takebayashi: "Surgical treatment for spinal disorders associated with long-term hemodialysis"Renal Failure and Surgical Therapy. 99, Vol.46. 28-34 (1999)

Manabu Ito、Kuniyoshi Abumi、Kiyoshi Kaneda、Kyoichi Hasekawa、Takehiro Takebayashi：“长期血液透析相关脊柱疾病的手术治疗”肾功能衰竭和手术治疗。

Manabu Ito, Kuniyoshi Abumi, Yasuhiro Shono, Yoshihisa Kotani, Akio Minami, Kiyoshi Kaneda: "Complications Related to Hydroxyapatite Vertebral Spacer in Anterior Cervical Spine Surgery"Spine. 27:4. 428-431 (2002)

Manabu Ito、Kuniyoshi Abumi、Yasuhiro Shono、Yoshihisa Kotani、Akio Minami、Kiyoshi Kaneda：“颈椎前路手术中与羟基磷灰石椎体间隔物相关的并发症”脊柱。

Kuniyoshi Abumi, Manabu Ito, Kiyoshi Kaneda: "Surgical treatment of cervical destructive spondyloarthropathy"Spine. Vol.25,No.22. 2899-2905 (2000)

Kuniyoshi Abumi、Manabu Ito、Kiyoshi Kaneda：“颈椎破坏性脊柱关节病的手术治疗”脊柱。

伊東 学, 鐙 邦芳, 金田清志, 長谷川匡一, 竹林武宏: "長期血液透析患者に特有な脊椎病変に対する手術治療"腎と透析, 別冊腎不全外科99. Vol.46別冊. 28-34 (1999)

Manabu Ito、Kuniyoshi Sugi、Kiyoshi Kaneda、Masakazu Hasekawa、Takehiro Takebayashi：“针对长期血液透析患者的脊柱病变的手术治疗”《肾脏与透析》，Bessatsu 肾衰竭外科 99。Vol.46 Bessatsu。 ）