Basal ganglia and autonomic functions.

基底神经节和自主功能。

基本信息

批准号：
10680699
负责人：
OTAKE Kazuyoshi
金额：
$ 1.86万
依托单位：
Tokyo Medical and Dental Univ., Graduate School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

Spontaneous and reactive behaviors are generated and homeostasis maintained by neural networks engaged in parallel distributed processing of multimodal environmental stimuli. Despite a wealth of evidence for afferents to diffuse and principal sensory relay nuclei of the thalamus from spinal cord, cerebellum and basal ganglia, anatomical substrates through which visceral afferents reach non-specific thalamic nuclei and thereby influence reactive behaviors and autonomic outflow appropriate to the physiological state of the organism are largely conjectural. Our goal was to define neural substrates, which regulate the visceral-limbic outflow in response to various environmental stimuli. First, we sought to determine the specific brain sites of action responsible for the centrally activating property of thyrotropin-releasing hormone (TRH) which, when administered centrally, produces a number of physiological and behavioral changes. In TRH administered rats, neurons in V/VI layers of pre-and … More infralimbic areas of medial prefrontal cortex, ventral midline thalamus, and nucleus of the solitary tract as well as adjacent reticular formation were selectively activated. These data suggest that various behavioral and autonomic responses induced by centrally administered TRH might be produced through the complex neural circuitry comprising above structures, mainly located in the area rostral to the pons. Second aim of our studies was to identify pathways of the efferents of the shell of the nucleus accumbens (Acb) to influence the outflow of the core of the Acb. Potential disynaptic projections of the shell to the core of the Acb were observed in the medial part of the ventral tegmental area, medial part of the lateral hypothalamic area, dorsolateral part of the basolateral amygdaloid nucleus. The significance of multiple sites of relay between the efferents of the shell and the afferents of the core of the Acb at different levels of the neuraxis may be related to the functional specificity of each relay site. Less

自发和反应性行为是产生的，并由从事多模式环境刺激的平行分布处理的神经网络维持的体内平衡。尽管有很多证据表明传入丘脑的传入和主要感官中继核与脊髓，小脑和基本神经节的证据，但内脏传入通过这些核的解剖基质，从而达到了非特异性丘脑核，从而影响反应性行为，并影响反应性行为，并适用于适当的构件的物理状态。我们的目标是定义中性底物，该底物调节对各种环境刺激的响应。首先，我们感觉到要确定负责甲状腺蛋白释放马酮（TRH）中心激活特性的特定大脑部位，该特性在中央施用时会产生许多生理和行为变化。在TRH施用的大鼠中，培养基前额叶皮层，腹部中线丘脑和固体核心和固体区域的核以及相邻的网状形成的介质前膜区域的v/vi层中的神经元被选择性地激活。这些数据表明，由中央施用的TRH引起的各种行为和自主响应可能是通过复杂的神经元电路产生的，该复杂神经元电路在上面的结构上面完成，该结构主要位于PON的区域。我们研究的第二个目的是确定伏隔核（ACB）壳的效果的途径，以影响ACB核心的出口。在腹侧对段区域的培养基部分，下丘脑面积的培养基部分，基底外侧杏仁核核核的一部分，在腹侧对段区域的培养基部分中观察到了壳向ACB核心的潜在无针子投影。在不同水平的神经毒性水平上，壳体的效果与ACB核心的传入之间的多个继电器的重要性可能与每个继电器位点的功能特异性有关。较少的