Clinicopathological Study of predictors of delayed cervical lymph node metastases in tongue carcinoma.

舌癌迟发性颈淋巴结转移预测因素的临床病理学研究。

• 批准号: 10671897
• 负责人: KIRITA Tadaaki
• 金额: $ 1.54万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671897/
• 关键词: tongue carcinoma; lymph node metastases; vascular endothelial growth factor (VEGF); Flt-4; predictor; 口腔癌; 頚部後発リンパ節転移; Ki-67; E-cadherin; VEGF; 免疫組織学的検索; 頸部後発リンパ節転移; 扁平上皮癌; 浸潤様式

Immunohistochemical study associated with delayed cervical lymph node metastases of squamous cell carcinoma of the tongue were investigated. Delayed cervical lymph node metastases were found in 8 (33.3%) of 34 patients with tongue carcinoma of stage I and II from October 1983 to June 1997. We examined the expression of vascular endothelial growth factor (VEGF), Flt-4, E-cadherin and Ki-67 and their relationship to delayed cervical lymph node metastases. The intensity of VEGF expression tended to correlate with delayed cervical lymph node metastases, but not significant (p=0.0845). The expression of E-cadherin and Ki-67 positive rate did not correlate with delayed cervical lymph node metastases (E-cadherin : p=0.8091, Ki-67 : p=0.8218). The vessel density in Flt-4-positive carcinomas was higher than that in Flt-4-negative carcinomas (p=0.0083). These findings suggest that the expression of VEGF and Flt-4 are probably predictors of delayed cervical lymph node metastases in tongue carcinoma.

研究了与舌头鳞状细胞癌的延迟宫颈淋巴结转移相关的免疫组织化学研究。在1983年10月至1997年6月的34例患有I和II期舌癌的患者中，有8例（33.3％）发现了延迟的宫颈淋巴结转移。我们检查了血管内皮生长因子（VEGF），FLT-4，E-4，E-Cadherin，E-Cadherin和Ki-67及其与延迟的颈椎乳腺乳腺乳酸node Metastases的关系。 VEGF表达的强度倾向于与延迟的宫颈淋巴结转移相关，但不显着（p = 0.0845）。 E-钙粘蛋白和KI-67阳性速率的表达与延迟的宫颈淋巴结转移无关（E-钙粘蛋白：P = 0.8091，KI-67：P = 0.8218）。 FLT-4阳性癌中的血管密度高于FLT-4阴性癌（P = 0.0083）。这些发现表明，VEGF和FLT-4的表达可能是舌癌中延迟的宫颈淋巴结转移的预测指标。