Local action of inhibin dimmer and α-monomer

抑制剂二聚体和α-单体的局部作用

• 批准号: 10671514
• 负责人: ABE Yumiko
• 金额: $ 0.77万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671514/
• 关键词: Inhibin; Inhibin Dimer; α monomer; Activin; Follistatin

Inhibin dimmer inhibits FSH secretion from anterior pituitary cells in primary culture and inhibin α-monomer has no effect on FSH secretion. But as reported so far, the action of inhibin is different from tissue to tissue. In order to establish a suitable system to investigate the action of inhibin, we investigated several cells using activin because the availability of inhibin is very limited and inhibin and activin use common receptors. (1) Pituitary cells : The regulation of PRL secretion by activin from a rat pituitary cell line with type-I and type-II activin receptor complex on the cell surface was investigated. PRL secretion was changed by activin. Further study regarding the involvement of the inhibin/activin signal in PRL production is useful for our study. (2) Ovarian cells : Granulosa cells from DES-primed immature rats and oocyte-granulosa-theca cell complex from immature mice reacted to activin in low concentrations. Therefore these cells seem to be suitable in order to study the action of inhibin dimmer and α-monomer. (3) Placental cells : A primary culture of human placental cells at term was investigated. Only high concentrations of activin changed the secretion of hCG so these cells do not seem suitable to use to investigate the local action of inhibin.

抑制剂抑制剂从原发性培养物中抑制垂体抗蛋白α-最小人物对FSH分泌没有影响，抑制素I的作用是抑制素的作用我们使用抑制素的激活素研究了严重性细胞，抑制蛋白使用常见的Eceptors（1）垂体细胞​​：刺激从具有I型和II型激活素受体X-Thine的大鼠垂体细胞系中的刺激素调节研究细胞表面的生产中的抑制素/激活素信号对我们的研究很有用。似乎适合研究抑制蛋白变暗者和胎盘细胞的作用。

项目成果

安部由美子: "下垂体と成長因子"産婦人科の世界. 52(3). 107-111 (2000)

阿部由美子：“垂体和生长因子”妇产科世界 52（3）（2000）。

T.Minegishi: "A role of insulin-like growth factor I for follicle stimulating hormone receptor (FSH-R) expression in granulosa cells"Iiol Reprod. 62. 325-333 (2000)

T.Minegishi：“胰岛素样生长因子 I 对颗粒细胞中卵泡刺激素受体 (FSH-R) 表达的作用”Iiol Reprod。

安部由美子 他: "インヒビン、アクチビン、フォリスタチン(新女性医学大系12排卵と月経)" 武谷雄二総編集 岡村 均担当編集 中山書店(東京), 401(107-124) (1998)

Yumiko Abe 等：“抑制素、激活素、卵泡抑素（新女性医学系统 12 排卵和月经）” Yuji Taketani，总编辑，Hitoshi Okamura，编辑，Nakayama Shoten（东京），401（107-124）（1998）

Liu-X: "Effects of growth hormone,activin,and ollistatin on the development of preantral folicle from immature female mice"Endocrinology. 139(5). 2342-2347 (1998)

刘-X：“生长激素、激活素和奥利司他对未成熟雌性小鼠腔前卵泡发育的影响”内分泌学。

安部由美子: "産婦人科の世界 第50巻 冬季増刊号 卵巣-機能と病態生理- インヒビン、アクチビン、ファリスタチン"医学の世界社. 68-76 (1998)

阿部由美子：“妇产科世界第 50 卷冬季特刊卵巢 - 功能和病理生理学 - 抑制素、激活素、Faristatin” Igaku no Sekaisha 68-76 (1998)。