ESTIMATION OF PERIOPERATIVE CARDIAC FUNCTION FOLLOWING PEDIATRIC CARDIAC SURGERY USING NONINVASIVE MEASUREMENT OF HIGH FREQUENCY QRS POTENTIALS

使用高频 QRS 电位的无创测量来估计小儿心脏手术后的围手术期心脏功能

• 批准号: 10671239
• 负责人: ATSUMI Naotaka
• 金额: $ 1.86万
• 依托单位: Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671239/
• 关键词: high frequency QRS potentials; pediatric cardiac surgery; ischemic reperfusion; myocardial injury; cardiac function; 心筋虚血; 加算平均心電図; 左室内圧-容積関係; 心収縮力

This study seeks to identify a new marker of intraoperative myocardial injury and perioperative cardiac function following pediatric cardiac surgery using high frequency QRS potentials.1) High frequency QRS potentials and perioperative myocardial injury following cardioplegic arrest in pediatric cardiac surgery : Signal-averaged electrocardiograms were recorded during open heart operation in 14 pediatric patients. The high frequency QRS potentials decreased at early reperfusion following cardioplegic arrest and then returned to preischemic levels. The recovery time of high frequency QRS potentials significantly correlated with arrest time and the post operative CK-MB values. The results suggest that myocardial injury in pediatric cardiac surgery can be assessed by changes in the high frequency ECG signals of the QRS complex.2) High frequency QRS potentials and the cardiac function. influence of hypoventilation : The changes in high frequency QRS potentials (RMS) and pressure volume relationship were studied in rat during hypoventilation. Emax, PRSW and RMS decreased during hypoventilation and returned during normal ventilation. There were good correlation between %RMS and %PRSW. The results suggest that decrease in cardiac function can be assessed by changes in RMS.3) High frequency QRS potentials and the cardiac function. isolated rat heart of Langendorff perfusion : The changes in high frequency QRS potentials (RMS) and cardiac function were studied in isolated rat heart of Langendorff perfusion during post ischemic reperfusion period. Left ventricular dp/dt, heart rate, rate-pressure-product and RMS decreased at early reperfusion following cardioplegic arrest and then returned to preischemic levels. The results suggest that the recovery of cardiac function after post ischemic reperfusion period can be assessed by changes in RMS.

这项研究旨在使用高频QRS潜力来确定儿科心脏手术后的术中心肌损伤和围手术期心脏功能的新标志。1）高频QRS电位和心骨损伤在儿科心脏外科手术后心phe骨抑制后记录了信号电动性电动性电动型电动型电动性电动膜损伤。在14名小儿患者的开放心脏手术中。心骨停滞后的早期再灌注时，高频QRS电势下降，然后恢复到牙周病前水平。高频QRS电位的恢复时间与停止时间和后手术CK-MB值显着相关。结果表明，小儿心脏手术中的心肌损伤可以通过QRS复合物的高频ECG信号的变化来评估。2）高频QRS电位和心脏功能。不足衰减的影响：在不足驱动过程中，研究了大鼠中高频QRS电位（RMS）和压力体积关系的变化。 EMAX，PRSW和RMS在不足衰减期间降低，并在正常通风期间返回。 ％rms和％PRSW之间存在良好的相关性。结果表明，可以通过RM的变化来评估心脏功能的减少。3）高频QRS电位和心脏功能。 Langendorff灌注的分离大鼠心脏：在缺血性再灌注期间，在Langendorff灌注的分离大鼠心脏中研究了高频QRS电位（RMS）和心脏功能的变化。心骨停滞后的早期再灌注时，左心室DP/DT，心率，速率压力产物和RMS降低，然后恢复到神学前水平。结果表明，缺血性再灌注周期后心脏功能的恢复可以通过RMS的变化来评估。

项目成果

Masakazu Abe, Naotaka Atsumi, Shounosuke Matsushita, Toshio Mitsui.: "High-frequency QRS potentials reflect myocardial injury following cardioplegic arrest in pediatric cardiac surgery"Pediatric Cardiology : in preparation.

Masakazu Abe、Naotaka Atsumi、Shounosuke Matsushita、Toshio Mitsui.：“高频 QRS 电位反映小儿心脏手术中心脏停搏后的心肌损伤”小儿心脏病学：准备中。

Abe M.,Atsumi N.et al.: "High frequency QRS potentials reflect myocardial injury following cardioplegic arrest in pediatric cardiac surgery"Pediatric Cardiology. (in preparation).

Abe M.、Atsumi N.等人：“高频 QRS 电位反映小儿心脏手术中心脏停搏后的心肌损伤”小儿心脏病学。