A Comparative Study on Aging Processes between Human and Nonhuman Primates based on Biological Age.

基于生物年龄的人类和非人灵长类动物衰老过程的比较研究。

基本信息

批准号：
10640690
负责人：
NAKAMURA Eitaro
金额：
$ 2.05万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10640690/
关键词：
Biological Age Humans Rhesus Monkeys Hematology Blood Chemistry 大動脈脈波速度チンパンジー

项目摘要

The purposes of this study were 1) to identify common biomarkers of aging between monkeys and humans to compare their aging rates ; 2) to reveal basic regularities of the aging process in monkeys which could apply to human ; and 3) to determine if caloric restriction retards the aging processes in primates as it does in rodents.The monkeys used in the present study were 33 male rhesus monkeys (19 young adult and 14 old monkeys). Half of subjects were assigned to experimental group subjected to 30% calorie restriction for 10 years compared to the control group. Subjects for humans were 122 Japanese adult men, who received a 2-day health examination at the Kyoto Red Cross Hospital for 7 years from 1992 to 1998. The 27 test variables selected from hematology and blood chemistry were used to find the candidate biomarkers of aging in monkeys.The results indicated that : 1) In monkeys, 9 variables of HGB and LYMPH from hematology and GOT, ALK PHOS, T-PRO, ALBU, AGR, CALC and DHEA from blood chemisty were selected as possible candidate biomarkers of aging ; 2) Of these 9 biomarkers, 4 variables of HGB, LYMPH, ALBU and CALC were identified to be able to use as biomarkers of aging in humans ; 3) Individual differences of aging are relatively less in monkeys than in humans. This difference between monkeys and humans might reflect the difference of longevity. In monkeys, the decline of physiological functions in a linear fashion may represent a decline in the ability of the organism to preserve homeostasis ; 4) we investigated the influence of CR on the rate of aging, using the biological index (BAS) of aging. The result indicates that the CR does not markedly extend life span as reported in rodents. It seems likely that moderate increases in life span will occur ; and 5) The rate of aging is faster by 3.46 times in monkeys than in humans.

本研究的目的是 1) 识别猴子和人类之间常见的衰老生物标志物，以比较它们的衰老速度； 2）揭示猴子衰老过程的基本规律，并适用于人类； 3) 确定热量限制是否会像啮齿动物一样延缓灵长类动物的衰老过程。本研究中使用的猴子是 33 只雄性恒河猴（19 只年轻猴子和 14 只老年猴子）。一半的受试者被分配到实验组，与对照组相比，该组的热量限制为 30%，为期 10 年。人类受试者为122名日本成年男性，从1992年至1998年连续7年在京都红十字医院接受了为期2天的健康检查。从血液学和血液化学中选出的27个测试变量用于寻找衰老的候选生物标志物结果表明： 1) 在猴子中，来自血液学的 HGB 和 LYMPH 9 个变量以及 GOT、ALK PHOS、T-PRO、血液化学中的 ALBU、AGR、CALC 和 DHEA 被选为衰老的可能候选生物标志物； 2) 在这9个生物标志物中，HGB、LYMPH、ALBU和CALC这4个变量被确定能够用作人类衰老的生物标志物； 3）猴子衰老的个体差异相对人类较小。猴子和人类之间的这种差异可能反映了寿命的差异。在猴子中，生理功能的线性下降可能代表机体维持体内平衡的能力下降； 4）我们利用衰老的生物学指数（BAS）研究了CR对衰老率的影响。结果表明，CR 并未显着延长啮齿动物的寿命。寿命似乎可能会适度延长； 5）猴子的衰老速度比人类快3.46倍。