A Comparative Study on Aging Processes between Human and Nonhuman Primates based on Biological Age.

基于生物年龄的人类和非人灵长类动物衰老过程的比较研究。

基本信息

批准号：
10640690
负责人：
NAKAMURA Eitaro
金额：
$ 2.05万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10640690/
关键词：
Biological Age Humans Rhesus Monkeys Hematology Blood Chemistry 大動脈脈波速度チンパンジー

项目摘要

The purposes of this study were 1) to identify common biomarkers of aging between monkeys and humans to compare their aging rates ; 2) to reveal basic regularities of the aging process in monkeys which could apply to human ; and 3) to determine if caloric restriction retards the aging processes in primates as it does in rodents.The monkeys used in the present study were 33 male rhesus monkeys (19 young adult and 14 old monkeys). Half of subjects were assigned to experimental group subjected to 30% calorie restriction for 10 years compared to the control group. Subjects for humans were 122 Japanese adult men, who received a 2-day health examination at the Kyoto Red Cross Hospital for 7 years from 1992 to 1998. The 27 test variables selected from hematology and blood chemistry were used to find the candidate biomarkers of aging in monkeys.The results indicated that : 1) In monkeys, 9 variables of HGB and LYMPH from hematology and GOT, ALK PHOS, T-PRO, ALBU, AGR, CALC and DHEA from blood chemisty were selected as possible candidate biomarkers of aging ; 2) Of these 9 biomarkers, 4 variables of HGB, LYMPH, ALBU and CALC were identified to be able to use as biomarkers of aging in humans ; 3) Individual differences of aging are relatively less in monkeys than in humans. This difference between monkeys and humans might reflect the difference of longevity. In monkeys, the decline of physiological functions in a linear fashion may represent a decline in the ability of the organism to preserve homeostasis ; 4) we investigated the influence of CR on the rate of aging, using the biological index (BAS) of aging. The result indicates that the CR does not markedly extend life span as reported in rodents. It seems likely that moderate increases in life span will occur ; and 5) The rate of aging is faster by 3.46 times in monkeys than in humans.

这项研究的目的是1）确定猴子和人类之间衰老的常见生物标志物以比较其衰老率； 2）揭示可能适用于人类的猴子衰老过程的基本规律； 3）为了确定热量限制是否像啮齿动物中那样降低了灵长类动物的衰老过程。本研究中使用的猴子是33位雄性恒河猴（19名年轻成人和14只老猴子）。与对照组相比，将一半的受试者分配给了30％卡路里限制10年的实验组。 Subjects for humans were 122 Japanese adult men, who received a 2-day health examination at the Kyoto Red Cross Hospital for 7 years from 1992 to 1998. The 27 test variables selected from hematology and blood chemistry were used to find the candidate biomarkers of aging in monkeys.The results indicated that : 1) In monkeys, 9 variables of HGB and LYMPH from hematology and GOT, ALK PHOS, T-PRO, ALBU,选择血液化学的AGR，计算和DHEA作为可能的衰老的候选生物标志物； 2）在这9个生物标志物中，HGB，淋巴，Albu和Calc的4个变量被确定为能够用作人类衰老的生物标志物； 3）在猴子中，衰老的个体差异要小于人类。猴子和人类之间的这种差异可能反映了寿命的差异。在猴子中，以线性方式的生理功能下降可能代表了生物体保持体内平衡能力的下降。 4）我们使用衰老的生物指数（BAS）研究了CR对衰老率的影响。结果表明，CR并未明显延长啮齿动物报告的寿命。似乎会发生适度的寿命增加。 5）猴子的衰老速度比人类快3.46倍。