Micro vascular architecture and bone formation after Guided Bone Regeneration

引导骨再生后的微血管结构和骨形成

基本信息

批准号：
08672105
负责人：
MATSUO Masato
金额：
$ 1.54万
依托单位：
Kanagawa Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672105/
关键词：
GBR SEM resin cast microcirculation GBR PTFE

项目摘要

Guided bone regeneration (GBR) is a periodontal treatment to restore the loss of alveolar bone. In the present study, nonresorbable and resorbable membranes were applied to the extraction socket / artificial bone cavity and vascular resin cast model was examined under scanning electron microscopy (SEM).In the observation of nonresorbable membrane, bone aposition was observed upward and sideways beyond the alveolar crest after 14 days postoperation. Regenerated blood vessels were distributed in the newly formed porous bone.30 days following surgery, In the center portion of the extraction socket, newly-formed vascular network and regenerated bone were observed. A flat vascular network from the periosteum was observed on the GBR membrane. 60 days following surgery, Regenerated bone and a vascular network of the bone marrow were observed.In the observation of resorvable membrane, 90 days after the operation, the membrane, which showed evidence of being resorbed, was found between the superficial vascular network of the oral mucosa and the regenerated alveolar bone. Blood vessels from the periosteum increased in caliber as they passed through the resorbed part of the membrane.These results indicate that regardless of what type of membrane is used, it only acts as a barrier preventing the oral mucosa from migrating apically to the socket, thereby creating an environment that promotes the proliferation of cells in the socket.From the viewpoint of the microcirculation, the level reached by blood vessels arising from the periosteum might play an important role in determining the final height of regenerated alveolar bone.

引导骨再生（GBR）是一种牙周治疗，可恢复肺泡骨的损失。在本研究中，在扫描电子显微镜（SEM）下检查了提取插座 /人造骨腔的不可吸附和可吸收的膜。在扫描电子显微镜（SEM）下进行了血管树脂铸造模型。在观察到不可吸收的膜膜，在14天后观察到骨aposion的骨骼悬垂。再生血管分布在新形成的多孔骨中。手术后30天，在提取插座的中心部分，观察到新形成的血管网络，并观察到再生骨。在GBR膜上观察到来自骨膜的平坦血管网络。手术后60天，观察到骨髓的再生骨和血管网络。在手术后90天的可吸收膜观察中，该膜在口腔粘膜的表面血管网络与再生的菌落骨骨之间发现了被吸收的证据。从骨膜中的血管穿过膜的吸收部分时，才能增加。这些结果表明，无论使用哪种类型的膜，它仅充当一个障碍，阻止口腔粘膜在座位上迁移到插座上，从而创造出一个促进细胞的环境。骨膜可能在确定再生肺泡骨的最终高度方面起重要作用。