Investigation of the brain stem function using three different parameters analyzing the relation among respiration, heart rate variability, and direct arterial pressure.

使用三个不同的参数研究脑干功能，分析呼吸、心率变异性和直接动脉压之间的关系。

基本信息

批准号：
08671741
负责人：
KAWAMOTO Masashi
金额：
$ 1.15万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671741/
关键词：
heart rate variability fast Fourier analysis impulse response analysis brain death

项目摘要

1st year :We developed analytical procedures using 3 different parameters from patients monitor ; heart rate variability (HRV) by measuring R-R interval segments from electrocardiogram (ECG), direct arterial pressure (DAP), and respiratory airway pressure (RAP) and endtidal CO2. We also started to develop computer program for this analysis. This analytical procedures are based on the fast Fourier analysis and impulse response analysis. With this computer program, we investigated the effects between RAP on HRV and HRV on DAP in the experimental animals and in the clinical conditions.2nd year :With this computer program, we continued to investigate the effects between RAP on HRV and HRV on DAP in the experimental animals and in the clinical conditions. In the model of brain-damaged rabbits, it was turned out that artificial respiration did not produce any effect of RAP on HRV,although HRV on DAP was dependent on the condition of brain damage. In clinical investigation in the intensiv care, HRV on DAP was apparent with the level of consciousness, while any effect of RAP on HRV was not observed. We have to improve the analytical procedure using RAP on HRV because the parameters represented by RAP and endtidal CO2 were not sufficient enough for the investigation. Instead of these parameters, thoracic impedance would be appropriate in the next step investigation.Conclusion :It was concluded that HRV was seriously depending on the respiratory condition although the subjects were artificially ventilated. However, it was not apparent that relation between RAP and HRV in both animal models and human studies. It is therefore further needed to investigate the relation between RAP and HRV,and between HRV and DAP for clinical application.

第一年：我们使用患者监测器的3个不同参数制定了分析程序；通过测量心电图（ECG），直接动脉压（DAP）以及呼吸道气道压力（RAP）和终点CO2的R-R间隔段，通过测量R-R间隔段和心率变异性。我们还开始开发计算机程序进行此分析。该分析程序基于快速的傅立叶分析和脉冲响应分析。通过该计算机程序，我们研究了RAP对实验动物和临床状况中HRV对DAP的RAP之间的影响。第2年：通过此计算机程序，我们继续研究RAP对HRV和HRV对实验动物DAP的影响以及在临床条件下。在脑部受损的兔子的模型中，事实证明，人工呼吸没有对HRV产生任何影响，尽管HRV对DAP的依赖于脑损伤的状况。在强化护理中的临床研究中，DAP上的HRV显然是意识水平的，而RAP对HRV的任何影响都没有观察到。我们必须在HRV上使用RAP改进分析程序，因为RAP和Endtidal CO2代表的参数不足以进行研究。与其这些参数不是这些参数，而是在下一步的调查中适当。结论：得出结论，HRV认真取决于呼吸条件，尽管受试者是人为地通风的。但是，在动物模型和人类研究中，RAP与HRV之间的关系很明显。因此，需要进一步研究RAP与HRV之间的关系，以及用于临床应用的HRV和DAP之间的关系。