Hepatocarcinogenetic Studies in Myanmar Thalassemiacs

缅甸地中海贫血患者的肝癌发生研究

基本信息

批准号：
08042005
负责人：
OKADA Shigeru
金额：
$ 5.82万
依托单位：
OKAYAMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

项目摘要

The aim of the present study is to make the epidemiological survey on the prevalence of iron overload and hepatocellular carcinoma (HCC)among Myanmar population, and clarify the association of iron overload with other factors such as hepatitis B and C virus (HBV and HCV) infection in the development of HCC.The survey was conducted from 24 December 1996 to 7 January 1997, and from 17 to 27 December 1997 at the Department of Medical Research ; the Section of Hepatology and Haematology, Yangon General Hospital ; and the Yangon Children's Hospital. 104 patients including 28 patients of HCC,38 thalassemiacs were surveyed. Their blood was collected with consent from the patients.The results were :l) Hepatitis virus markers : 94% of the liver patients had the past history of HBV infection. Persistent HBV infection was found in 36 patients (35%). HCV-RNA positivity that means persistent HCV infection was 79% among anti-HCV antibody positive patients. 31% of the total patients was suspected to have persistent HCV infection. 46% of HCC was related to HBV only was, 7% to both HBV and HCV,21.4% to HCV.HCV infection were more prevalent among transfuction dependent thalassemiacs. 52% were positive for anti-HCV antibody, and41% are suspected to have persistent HCV infection.2)Iron overload status : Almost all the patients survey had some kind of abnormalities concerning iron metabolism. Two thirds of the hepatology patients showed low TIBC.All the thalassemiacs showed increased transferrin iron saturation and free iron (Gutteridge method).Surprising findings among Myanmar in-patients were the epidemic of hepatitis C virus infection. It is felt imperative to combat the epidemic. Another surprising findings about HCV infection was the identified virus subtype was all lb. Survey system for hepatitis C must be constructed. lron overload found among patients with liver disease must be treated.

本研究的目的是对缅甸人口中铁超负荷和肝细胞癌（HCC）的流行病学进行调查，并阐明铁过载与其他因素与肝炎病毒（HBV和HCV）（HBV和HCV）在HCC开发中的研究中的相关性（HBV和HCV）在199年12月24日至1997年12月7日在1997年12月7日进行的研究中，并进行了研究。 ;仰光综合医院肝病学和血液学部分；和仰光儿童医院。 104例患者包括28例HCC患者，调查了38例丘脑症。他们的血液是在患者同意的情况下收集的。结果是：l）肝炎病毒标志物：94％的肝脏患者有HBV感染的史。在36例患者中发现了持续的HBV感染（35％）。抗HCV抗体阳性患者的HCV-RNA阳性意味着持续性HCV感染为79％。怀疑总患者的31％被怀疑患有持续的HCV感染。 HBV仅与HBV有关，HBV和HCV的HBV仅为46％，HCV.HCV感染的21.4％在依赖于Thalassemiacs中更为普遍。 52％的抗HCV抗体为阳性，怀疑有41％的HCV感染。2）铁超载状态：几乎所有患者调查都有与铁代谢有关的某种异常。三分之二的肝病患者表现出较低的TIBC。所有丘疹症表现出升高的铁蛋白铁饱和度和游离铁（Gutteridge方法）。缅甸患者患者中的苏次发现是丙型肝炎病毒感染的流行。抗击流行病是必要的。关于HCV感染的另一个令人惊讶的发现是，必须构建所有针对丙型肝炎的病毒亚型。必须治疗肝病患者中发现的LRON超负荷。