Development of high temperature cancer therapeutic system using high intensity focused ultrasou

利用高强度聚焦超声波开发高温癌症治疗系统

基本信息

批准号：
07557104
负责人：
IORITANI Naomasa
金额：
$ 13.5万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

In order to establish the cancer therapy system, effect of the high intensity focused ultrasound heating was studied on the normal tissue and the experimental cancer tissue. The ultrasound source was a spherical piezo-ceramic peace that was applied to the tissue through water cushion. At first step, we used the conventional single frequency wave (SFW) driving, whose single burst for one second at 400 watts was effective enough to raise the temperature of focus area up to 100 degrees centigrade. The focused area showed an oval-shaped coagulation necrosis. The tissue structure of the focus was relatively preserved. However, this area was surrounded by a thin (0.5 - 1mm) annular zone with massive deformity of tissue structure. This zone was sharply demarcated by the normal surrounding area. However, when the bursts were given in a series to heat a certain volume, the focus temperature of later bursts could not achieve that of the first burst. The coagulation area also shifted to the sound source. These phenomena were due to cavitation of the ultrasound pass. we then interposed the frequency modulated wave between SFWs. This modification (Cavitation Suppression Technique : CAST) was so effective that posterior wall of rabbit bladder was effectively coagulated in contrast to subtle change by SFW.We also tried the focus size modification by using phase difference driving, in which the piezoceramic elements were divided into twelve pieces. The focus size increased to 10 mm with this device. This enlarged and attenuated focus was also effective to prevent the bumping in tissue which was frequently observed in liver with SFW without and with CAST.Using these devices, some tumors of mice and rabbits were effectively treated, however, tumor recurrence on peripheral area of tumors and in blood vessels were frequently observed. We are also working on the combination of chemotherapeutic agents and tumor immunology.

为了建立癌症治疗系统，研究了高强度聚焦超声加热的影响，对正常组织和实验性癌症组织进行了研究。超声源是一种球形压电 - 陶瓷和平，通过水垫应用于组织。在第一步，我们使用了常规的单频波（SFW）驾驶，其在400瓦的单次爆发足以将重点区域的温度提高到100摄氏度。聚焦区域显示椭圆形凝血坏死。焦点的组织结构相对保留。但是，该区域被薄（0.5-1mm）的环形区域包围，并具有大量的组织结构畸形。该区域被正常的周围区域彻底划定。但是，当爆发以一系列加热一定体积时，后来突发的聚焦温度无法达到第一爆发的温度。凝结区也转移到了声源。这些现象是由于超声通行证的空化引起的。然后，我们插入了SFW之间的频率调制波。这种修饰（空化抑制技术：铸造）是如此有效，以至于与SFW的微妙变化相比，兔膀胱的后壁有效地凝结了。我们还尝试使用相位差驱动器进行了焦点尺寸的修改，在该驱动器中，将压电的元素分为十二块。使用此设备的焦点尺寸增加到10毫米。这种扩大和减弱的焦点也有效地防止组织中经常观察到的组织中经常观察到的肝脏，并没有铸造。但是，经常观察到一些小鼠和兔子的肿瘤，但是，经常观察到肿瘤对肿瘤和血管周围区域的肿瘤复发。我们还致力于化学治疗剂和肿瘤免疫学的组合。