Autocyclases: A new class of self-cyclising proteins

自环化酶：一类新的自环化蛋白

• 批准号: DP220103028
• 负责人: Prof Mehdi Mobli
• 金额: $ 31.12万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-21 至 2025-01-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103028
• 关键词: Autocyclases; new; class; self; cyclising

The biotechnology sector is emerging as an important economic strength in Australia. While the improved efficacy and selectivity of biomolecules has seen them emerge as alternatives to existing chemicals in health and agriculture, the stability of biomolecules remains a major limiting factor. A general strategy for improving protein stability is by joining the ends of the peptide chain in a cyclisation reaction. While a wide range of cyclic peptides and proteins are being developed in Australia and around the world, the cyclisation reaction presents a significant challenge. In this proposal we detail a novel method for protein cyclisation as a general, low-cost and green production method for making a diverse range of biomolecules.

生物技术部门正在成为澳大利亚的重要经济实力。尽管生物分子的疗效和选择性的提高使它们成为健康和农业中现有化学物质的替代品，但生物分子的稳定性仍然是主要的限制因素。提高蛋白质稳定性的一般策略是将肽链的末端连接到循环反应中。虽然在澳大利亚和世界各地开发了广泛的环状肽和蛋白质，但循环反应带来了重大挑战。在此提案中，我们详细介绍了一种新型的蛋白质环化方法，作为一种一般，低成本和绿色生产方法，用于制造各种生物分子。