The experimental and clinical microphthalmos

实验和临床小眼球

• 批准号: 05404059
• 负责人: MAJIMA Akio
• 金额: $ 6.21万
• 依托单位: NAGOYA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05404059/
• 关键词: congenital microphthalmos; definition of microphthalmos; pathogenic classification; neural crest cell; glycosaminoglycans molecular species; レチノイン酸; Ctsマウス; 小眼球症眼瞼; グリコサミノグリカン; CHARGE連合; 神経堤細胞発生異常; 組織化学; Bruch膜; 水晶体胞分離; 前眼部間葉異発生; 胎児性アルコール症候

Congenital microphthalmos is a conmmon malformation encountered clinically. Microphthalmos in adults is here defined as eyes whose axial length is below 20.4 mm in males and 20.1 mm in females ; in under 14-year-old children, it is eye at least √^3<2/3> below the mean for age-similar controls. Experimental animals with hereditary microphthalmos have been widely investigated, and many environmental factors given to pregnant animals frequently induce microphthalmos. In both clinical and experimental microphathalmos, there are conspicuous variations in size, and various kinds of ocular and systemic complications. Recently, fetal alcohol syndrome produced by alcohol intake during pregnancy has been mported. In this syndrome, microphthalmos is one of the important symptoms. Experimentally, microphthalmos also developed at a high incidence among mouse fetuses whose mothers were given ethanol during pregnancy. The present investigator established a preliminary etiological classification of microphthalmos in 1984. In this paper summing up newly obtained results, the relationship to neural crest cells and histochemical changes of glycosaminoglycans molecular species, the author presents a final pathogenic classification of microphthalmos, which consists of developmental disturbance of the optic vesicle, malformation of the optic cup, mesenchymal dysgenesis of the anterior ocular segment, maldevelopment of the lens, maldevelopment of the vitreous, faulty closure of the embryonie fissure and developmental disturbance of the wall of eyeball.

先天性小眼球是临床上常见的畸形，此处定义为男性眼轴长度低于20.4毫米，女性眼轴长度低于20.1毫米，14岁以下儿童眼轴长度至少为√^3<低于同龄对照组平均值的 2/3> 患有遗传性小眼球的实验动物已被广泛研究，并且怀孕动物的许多环境因素经常诱发。小眼球在临床和实验中都存在明显的大小差异，并且存在各种眼部和全身并发症，近来，妊娠期间饮酒引起的胎儿酒精综合征是其中重要的一种。实验上，母亲在怀孕期间服用乙醇的小鼠胎儿中，小眼球的发病率也很高。本研究人员于 1984 年建立了小眼球的初步病因学分类。本文总结了新获得的结果、与神经嵴细胞的关系以及糖胺聚糖分子种类的组织化学变化，作者提出了小眼球的最终致病分类，包括视囊发育障碍、视杯畸形、间质发育不全眼前段发育不良、晶状体发育不良、玻璃体发育不良、胚胎裂隙闭合不良以及眼球壁发育障碍。

项目成果

Mizuno Shin-ichi: "Histochemical studies of the separation of the lens besicle in the mouse" Japanese Journal of Ophthalmology. 39. 340-346 (1995)

Mizuno Shin-ichi：“小鼠晶状体小球分离的组织化学研究”日本眼科杂志。

尾関 年則: "全身異常を伴った後部胎生環の6例" 臨床眼科. 50(印刷中). (1996)

Toshinori Ozeki：“后胚胎环全身异常的六例”临床眼科 50（出版中）。

水野 晋一・他: "水晶体胞分離過程の組織化学的検索" 日本眼科学会雑誌. 101・1. 46-51 (1997)

Shinichi Mizuno等：“晶状体囊肿分离过程的组织化学研究”日本眼科学会杂志101・1（1997）。

尾関年則: "後部胎生環の臨床的検討" 臨床眼科. 48(印刷中). (1994)

Toshinori Ozeki：“后胚胎环的临床检查”临床眼科 48（出版中）。

Ozeki H.: "Clinical evaluation of posterior embryotoxon in one institution."Jpn J Ophthalmol. 41. 422-425 (1997)

Ozeki H.：“一个机构对后胚胎毒素的临床评估。”Jpn J Ophamol。