DEVELOPMENT OF FUNCTIONALLY GRADIENT DENTAL MATERIALS FOR CLINICAL USE

开发临床使用的功能梯度牙科材料

基本信息

批准号：
05557087
负责人：
WATARI Fumio
金额：
$ 7.94万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05557087/
关键词：
Functionally gradient materials Implant Biobompatibility Atomic force microscopy In situ observation Mechanical properties Titanium Apatite 歯科用インプラント人工歯根 CIP

项目摘要

To apply functionally gradient materials (FGM) for dentistry and develop for clinical use the functionally gradient dental implants composed of the metal titanium (Ti) and ceramics hydroxyapatite (HAP) were made and tested. HAP,which has the excellent biocompatibility with bone, is brittle and easily results in fracture in the ptactical use. Ti, one of the best biocompatible metals, can maintain the mechanical toughness. The implant was designed to provide more Ti for the upper part where the occlusal force is directly imposed and more HAP for the lower part which is implanted in side the jawbone. After the fundamental research of preparation method, choice of materials, mechanical test and microanalysis, animal test was done to estimate the biocompatibility. The in-situ observation of change of surface morphology of human enamel and dentin immersed in etching agents was also done using atomic force microscopy. The principal accomplishments were as follows ;1.Preparation : Mixed powders with the different composition packed from part to part into the silicon rubber mold were compressed at the pressure 400MPa by CIP.The compact was sintere in the argon gas by high frequency induction heating at 1300ﾟC.2.Mechanical Properties : The compressive and flexural tests were done. The average flexural strength of the FGM specimens was 150 MPa which is approximately comparative to the human bone strength.3.Observation & Analysis : The surface and cross-section observed by optical and electron microscopy showed the distribution of porosity and HAP in the Ti matrix. The gradual change of concentration was confirmed by the analysis of elemental distribution using EPMA.4.Biocompatibility : The implant test into the femora of rats was done to estimate the biocompatibility. Newly formed bone was partially in contact with the implant in the case of Ti, wheras in the Ti/HAP FGM new bone was in contact with the most part of the implant.

为了将功能性梯度材料（FGM）应用于牙齿和开发临床用途，制造并测试了由金属钛（TI）和陶瓷羟基磷灰石（HAP）组成的功能梯度牙齿。 HAP与骨骼具有出色的生物相容性，在术中易于脆弱，很容易导致骨折。 Ti是最好的生物相容性金属之一，可以保持机械韧性。该植入物旨在为上部提供更多的TI，其中咬合力是直接施加的，而下部植入颌骨侧面的下部则更多。在制备方法的基本研究，材料的选择，机械测试和微分析之后，进行了动物测试以估计生物相容性。也使用原子力显微镜进行了浸入蚀刻剂的人搪瓷和牙本质表面形态变化的原位观察。主要成就如下。 ; 1.制备：与硅橡胶模具的不同组合物的混合粉末在400mpa的压力下通过CIP压缩。紧凑型在1300 c.2.c.2.c.2的高频感应加热中是氩气的颗粒：压缩和挠曲测试是完成的。 FGM样品的平均弯曲强度为150 MPa，与人骨强度大致相比。3。观察和分析：光学和电子显微镜观察到的表面和横截面显示Ti矩阵中孔隙度和HAP的分布。通过使用EPMA对元素分布进行分析，确认了浓度的等级变化。4。生物相容性：进行大鼠股骨的植入测试以估计生物相容性。在Ti的情况下，新形成的骨骼与植入物接触，而Ti/Hap FGM中的新骨与大部分植入物接触时。