High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors

用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器

基本信息

批准号：
RGPIN-2015-05188
负责人：
Charette, Paul
金额：
$ 3.24万
依托单位：
Université de Sherbrooke
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2022
资助国家：
加拿大
起止时间：
2022-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=754110
关键词：
resolution multimodal SPR imaging instrumentation

项目摘要

Biosensors, also known as labs-on-a-chip, are bioanalytical devices designed for use in personalized medicine, rapid medical diagnostics, drug discovery and environmental analysis. Most biosensors work by chemically detecting specific "biomolecular markers" such as pathogens or environmental contaminants. There are many applications, however, for which no reliable markers can be found. In such cases, "higher-level" biosensors based on live biological cells are a powerful alternative. Indeed, cells are complex self-contained miniaturized machines that can be used as the basis for biosensing, where the cell response to its environment is in itself the sensing mechanism. Recent advances in nanotechnology and theoretical understanding of sub-wavelength phenomena in plasmonics have opened up many new and exciting possibilities for miniaturized biosensing. My research program over the next 5 years seeks to capitalize on these advances by developing novel high-resolution multi-modal instrumentation designed to discover new enabling knowledge on how cells react to changes in their local environment in response to the presence of disease factors, pathogens, or contaminants. This new knowledge will lead to the development of next-generation cell-based biosensors designed to address some of the most pressing needs in critical care and personalized medicine.

生物传感器，也称为芯片实验室，是一种生物分析设备，设计用于个性化医疗、快速医疗诊断、药物发现和环境分析。大多数生物传感器通过化学方法检测特定的“生物分子标记”，例如病原体或环境污染物。然而，有许多应用无法找到可靠的标记。在这种情况下，基于活生物细胞的“高级”生物传感器是一个强大的替代方案。事实上，细胞是复杂的独立微型机器，可以用作生物传感的基础，其中细胞对其环境的反应本身就是传感机制。纳米技术的最新进展和对等离激元亚波长现象的理论理解为小型化生物传感开辟了许多新的、令人兴奋的可能性。我未来 5 年的研究计划旨在通过开发新型高分辨率多模式仪器来利用这些进步，旨在发现有关细胞如何对局部环境变化做出反应以应对疾病因素、病原体的存在的新知识。，或污染物。这些新知识将促进下一代基于细胞的生物传感器的开发，旨在满足重症监护和个性化医疗中一些最紧迫的需求。