Characterization of Solute Transport Processes in Fishes

鱼类溶质运输过程的表征

• 批准号: RGPIN-2022-03405
• 负责人: Goss, Gregory
• 金额: $ 2.84万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744744
• 关键词: Characterization; Solute; Transport; Processes; Fishes

This research will investigate the functional evolution of ion, acid-base, and solute transporters and their unique roles in helping fish to cope with extreme environments. I will study a variety of acid-tolerant and acid-intolerant freshwater fish species will be undertaken to investigate the molecular mechanisms responsible for allowing certain freshwater fish to occupy waters with very low ion concentrations and low pH. In marine environments, the research will examine the unique adaptations in ion, acid-base, and solute transporters that enable the opportunistic rotting carcass scavenging Pacific hagfish possess to survive in a putrefying environment inside these carcasses. We will examine how the unique stress steroid profiles in hagfish may be linked to the unique strategy of ionoconforming in the plasma of  hagfish impact and shed light on how hagfish can controls their ion and acid base regulation. This research explores the fundamental nature of the evolution of solute transporter and will integrate these traits into the current evolutionary theories of vertebrate evolution. The results of this research will be of intense interest to evolutionary scientists, comparative physiologists, fisheries managers, and biomedical scientists.

这项研究将调查离子、酸碱和溶质转运蛋白的功能进化及其在帮助鱼类应对极端环境中的独特作用，我将研究各种耐酸和不耐酸的淡水鱼类。研究导致某些淡水鱼生活在离子浓度极低和 pH 值低的水域的分子机制。在海洋环境中，该研究将研究离子、酸碱和溶质转运体的独特适应，从而使尸体机会性腐烂。食腐太平洋盲鳗必须在这些尸体内的腐烂环境中生存，我们将研究盲鳗中独特的应激类固醇特征如何与盲鳗血浆中离子顺应的独特策略相关联，并揭示盲鳗如何控制其离子。这项研究探索了溶质转运蛋白进化的基本性质，并将这些特征整合到当前脊椎动物进化的进化理论中。这项研究的结果将引起人们的极大兴趣。进化科学家、比较生理学家、渔业管理者和生物医学科学家。