Noninvasive studies of central control of voluntary movement and language

随意运动和语言的中枢控制的无创研究

基本信息

批准号：
03404030
负责人：
KIMURA Jun
金额：
$ 15.94万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03404030/
关键词：
voluntary movement central control noninvasive studies movement-related cortical potentials movement-related magnetic field PET regional cerebral blood flow subdural recording 硬膜下電極局所脳血流量

项目摘要

Elucidation of generator sources of movement-related cortical potentials By subdural recording in patients with intractable epilepsy, the early electric potential starting about 2 s before the onset of voluntary finger movement (readiness potential) was found to be generated from the hand area of the supplementary motor area (SMA) and that of the primary motor area (M1), both bilaterally. The late negative slope preceding the movement onset by 300 ms was generated more from the contralateral SMA and M1.Recording of movement-related magnetic field Magnetic field as sociated with voluntary finger movement was recorded by 7-as well as by 37-channel magnetometer, and the, generator sources of components immeiately preceding and following the movement onset were clarified.Comparis on of simple and complex movements Scalp potentials preceding complex sequential finger movements were compared with those preceding simple simultaneous movements, and the former was found to be associated with more activation not only of SMA but also of bilateral Mlthan the latter.Functional imaging by PET Simple and complex finger movements were compared by measuring an increase of regional cerebral blood flow with PET, and showed an evidence supporting the above electrophysiological findings.Thus, these noninvasive studies clarified the important roles playd by not only SMA but also M1 in the planning and/or execution of voluntary finger movements in humans.

发现，在自愿手指运动发作之前大约2 s的早期电位（准备就绪）是从补充运动区域（SMA）的手部（SMA）以及两边的初级运动区域（M1），两者都会产生，从而阐明了具有顽固性癫痫患者的运动相关皮层潜能的发电源，早期电位的早期电位（准备就绪）。在对侧SMA和M1中产生了更多在运动开始前的晚期负斜率。随着7-e及37频道磁力计的自愿运动记录，与运动相关的磁场磁场的记录是由自愿运动的社会记录的，并记录了37通道磁力计，以及均质的动作范围的均匀范围。将复杂的顺序手指运动与先前简单同时运动的那些运动进行比较，并且发现前者不仅与SMA的激活相关，而且还与后者的双边运动相关联。宠物简单且复杂的手指的功能成像是通过测量与宠物的较重要研究的增加，并通过衡量了较重要的研究，以上是cliriptif的clirassightive coolipers coolifie the Electiftim the dighting。角色不仅由SMA扮演，还包括M1在人类自愿运动的计划和/或执行中。