Comparative study on female lung cancer in Japan, USA, China

日本、美国、中国女性肺癌比较研究

基本信息

批准号：
03042015
负责人：
NAKANISHI Yoichi
金额：
$ 2.24万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03042015/
关键词：
Lung Cancer Female Fuyuan, Yunnan, China Mortality Ratio Carcinogen Benzopyrene 1-Nitopyrene 腺癌変異原性

项目摘要

Although the relationship between cigarette smoking and lung carcinogenesis is clear, it is said smoking is not common in female adenocarcinoma patients. The purpose of this study is to analyze the factors for lung carcinogenesis in females, especially non-tobacco factors.In our survey lung cancer mortality ratio(LCMR) in Fuyuan County, Yunnan Province, China was markedly high compared to that in whole China(51.9 vs 5.0/100,000), male to female ratio of LCMR in Fuyuan is 1.81, and LCMR in northern communes in Fuyuan was higher than that in southern. In Fuyuan more than 90% people are farmers, and the Han race. Smoking habit in females are rare. One of the major industries is coal mining, and they produce smoky coal in northern area and smokeless in southern. Traditionary they use coal for indoor cooking, heating and ham smoking.Soot collected from the houses of northern Fuyuan contained high mutagenic activities against Salmonella typhimurium(SA). Coal combustion emission derived from smoky coal produced in northern Fuyuan contained higher mutagenic activity than smokeless coal in southern. 21 resected lung specimens derived from lung cancer patients in Fuyuan and 137 specimens in Japan were analyzed for carcinogen content and mutagenic activiries. In Chinese samples higher concentration of benzopyrene (608.7*477.1pg/g dry weight in Chinese vs 180.3*103 in Japanese) and higher mutagenic activity to SA(YG1204, +S9) were detected. On the other hand, in Japanese samples higher concentration of 1-nitopyrene(21.3*12.4pg/g dry weight in Japanese vs 5.9*2.4 in Chinese) and higher mutagenic activity to SA(YG1029, -S9) were detected.These results suggest that1)in Fuyuan, life style, indoor environment and high concentration of carcinogen in coal combustion emission maybe the causes of high LCMR in. females,2)potent lung carcinogens in the atmosphere may different in Fuyuan and Japan.

尽管吸烟与肺癌发生之间的关系很明显，但据说吸烟在女性腺癌患者中并不常见。这项研究的目的是分析女性的肺癌发生因素，尤其是非烟草因素。在我们的调查中，中国云南省福尤恩县的肺癌死亡率（LCMR）显着高，与整个中国相比，与全国（51.9 vs 5.0/100,000）相比，lcmr and lcmr in of lcmr in fuy in fuy ins and fuy and in fuy and。富尤的公社高于南部的公社。在富尤，有90％以上的人是农民和汉族。女性的吸烟习惯很少。主要行业之一是煤矿开采，它们在北部地区生产烟熏煤，南部无烟。传统上，他们将煤炭用于室内烹饪，供暖和火腿吸烟。从北部富尤北部的房屋中收集的烟雾含有高的诱变活动，反对沙门氏菌（SA）。富尤北部生产的烟煤衍生而成的煤炭燃烧发射比南部的无烟煤炭更高。分析了21种源自富尤肺癌患者的肺标本，日本分析了137个标本的肺癌标本和诱变性诱变。在中国样品中，检测到了较高的苯二苯二酚（608.7*477.1pg/g中国的干重，而日语中的180.3*103）和SA的较高诱变活性（YG1204， +S9）。 On the other hand, in Japanese samples higher concentration of 1-nitopyrene(21.3*12.4pg/g dry weight in Japanese vs 5.9*2.4 in Chinese) and higher mutagenic activity to SA(YG1029, -S9) were detected.These results suggest that1)in Fuyuan, life style, indoor environment and high concentration of carcinogen in coal combustion emission maybe the causes of high LCMR in.女性，2）在富尤和日本，大气中有效的肺癌可能会有所不同。