Periodic Changes of Muscle in Denervated Muscle and Vascularized Muscle Graft

去神经肌肉和血管化肌肉移植物中肌肉的周期性变化

• 批准号: 02807137
• 负责人: KOSHIMA Isao
• 金额: $ 1.02万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02807137/
• 关键词: denervated muscle; vascularized muscle grafts; vascularized nerve graft; reinnervation; facial palsy; brachial nerve palsy; head and neck reconstruction; 頭頚部癌; 筋管細胞; 筋芽細胞; 遊離筋肉移植; 血管柄付筋肉移植; 神経再生; 線維芽細胞成長因子; 人工神経; ファ-タ-パチニ小体; 知覚終末; 切断肢

1. Using denervated gastrocunemius muscles of rats, it was suggested that degenerated original muscle fibers were replaced by regenerated muscle cells including myoblasts and myotubes without reinnervation.2. It was found that over three months of denervated periods., morphologic structure of denervated muscles could not recover that of normal one.3. In vascularized muscle grafts, it was found that regenerated muscle cells developed to become normal muscle fibers after degeneration of transplanted original muscle fibers.4. In biopsied nerves and muscles in paralytic patients, numerous regenerated axons and regenerated muscle cells could be detected.5. Based on these experimental results, new surgical methods were developed for clinical patients. Cross-face nerve grafts using free vascularized deep peroneal nerve were successfully transferred to reconstruct facial paralysis. Also, free vascularized femoral muscle transfer were successfully used for repair of the patients with established facial parlaysis, brachial nerve palsy. and wide facial defects due to head and neck cancers.

1。使用不死的大鼠胃肌肉肌肉，建议将重新的原始肌肉纤维替换为重生的肌肉细胞，包括成肌细胞和肌管，而无需重新连接。2。已经发现，在三个月的未成年时期，被取消的肌肉的形态结构无法恢复正常的1.3。在血管化的肌肉移植物中，发现在移植的原始肌肉纤维退化后，再生的肌肉细胞成长为正常的肌肉纤维。4。在瘫痪患者的活检神经和肌肉中，可以检测到许多再生轴突和再生肌肉细胞。5。基于这些实验结果，为临床患者开发了新的手术方法。使用游离血管化的深膜神经的跨面神经移植成功地转移到面部瘫痪中。此外，成功使用了自由血管化的股骨转移，用于修复既定的面部帕氏菌，臂神经麻痹的患者。以及由于头部和颈部癌症引起的宽面部缺陷。

项目成果

Koshima,I.: "Experimental study of growth associated proteins related to nerve regeneration on: Periodic observations in nerve graft models utilizing fluography." Transactions of 3rd Vienna Muscle Symposium, (1991)

Koshima,I.：“与神经再生相关的生长相关蛋白的实验研究：利用荧光成像技术定期观察神经移植模型。”

光嶋 勲: "軸索内輸送と細胞骨格" 日手会誌. 7. 1-4 (1991)

Isao Mitsushima：“轴突运输和细胞骨架”日本学会杂志 7. 1-4 (1991)。

Koshima,I.: "Free second toe transfer for reconstruction of the distal phalanx of the fingers." Brit.J.Plast.Surg.44. 456-458 (1991)

小岛，I.：“免费第二脚趾移植，用于重建手指远端指骨。”

Koshima,I.: "Osteocutaneous flap from the big toe for repair of osteomyelitis of the second toe." Ann.Plast.Surg.25. 283-286 (1990)

小岛，I.：“大脚趾骨皮瓣用于修复第二脚趾骨髓炎。”

光嶋 勲: "軸索内輸送と細胞骨格" 日手会誌. 7. (1991)

Isao Mitsushima：“轴突内运输和细胞骨架”日本学会杂志 7。（1991）。