A Study on Biomechanics of Growth/resorption of Biological Tissue as Functional Adaptation

生物组织生长/吸收的生物力学作为功能适应的研究

基本信息

批准号：
02805014
负责人：
MORIMOTO Yoshiharu
金额：
$ 1.15万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02805014/
关键词：
Biomechanics Mechanical Adaptation Remodeling Bone Intervertebral Disc Aorta Tendon リモデリング成長と変性

项目摘要

The biological issues and systems have the ability to grow, resorb, and/or deform themselves according to the changes of their environments and routine behaviors. Such ability of mechanical adaptation by remodeling is intrinsic only to the biological issue and systems. The quantitative observation and its model description are fundamental in understanding such phenomena and applying such a function in engineering field. From this viewpoint, this study investigates the following topics from experimental/mathematical approaches.1. Residual stress in bone and model of remodelingThe residual stress was released from the rabbit tibia-fibula system by the cutting method. It is found that the observed residual stress is comparable to that by the selfweight and its distribution is complex over the tibia. A model was proposed for the bone remodeling permitting the existence of the residual stress in the bone. The basic capability of the model was examined by simple case studies combined with the observed residual stress.2. Experimental spondylosis model and effect of overuseThe experimental spondylosis was established by surgicalintervention in mice. Mechanical instability accelerates the process of intervertebral disc degeneration and the long term instability brings the spondylosis. Repetitive extension-flexion was loaded on spine of rabbits, and the delamination of annulus fibrosus and the early osteophyte formation are observed. This suggests the overuse is a factor in the pathogenesis of spondylosis.3. Mechanical adaptation of aorta and patellar tendonGoldblatt hypertension was induced in rats and it is found that the aortic wall changes in morphology first and then in the mechanical properties adoptng itself to the mechanical environment. The stress shielding in the patellar tendon of rabbits leads the immediate decrease of the mechanical properties and the reloading brings the gradual recovery. These results show the rapid mechanical adaptation in soft tissues.

生物学问题和系统具有根据环境和常规行为的变化而成长，悠久和/或变形的能力。通过重塑的机械适应能力仅是生物学问题和系统的固有性。定量观察及其模型描述对于理解这种现象并在工程领域中应用这种功能至关重要。从这个角度来看，这项研究研究了实验/数学方法的以下主题1。骨骼中的残余应力和重塑模型通过切割方法从兔胫骨系统中释放出残留应力。发现观察到的残留应力与自重量相比，其分布在胫骨上很复杂。提出了一个模型，用于骨骼重塑，允许骨骼中存在残留应力。通过简单的案例研究与观察到的残余应力相结合，检查了模型的基本能力。2。实验性脊椎病模型和过度使用实验性脊椎病的作用是通过小鼠手术干扰建立的。机械不稳定性加速了椎间盘退化的过程，长期不稳定性会带来脊椎病。重复的延伸反射量被加载在兔子的脊柱上，并观察到环纤维的分层和早期的骨植物形成。这表明过度使用是脊椎病发病机理的一个因素3。主动脉和tellardongoldblatt高血压的机械适应性在大鼠中诱导，并发现主动脉壁首先会变化形态的变化，然后在机械性能中采用的机械性能本身对机械环境。兔子tellar肌腱中的应力屏蔽导致机械性能的立即降低，并且重新加载带来逐渐恢复。这些结果表明软组织中的机械适应性快速。