A Study on Biomechanics of Growth/resorption of Biological Tissue as Functional Adaptation

生物组织生长/吸收的生物力学作为功能适应的研究

基本信息

批准号：
02805014
负责人：
MORIMOTO Yoshiharu
金额：
$ 1.15万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02805014/
关键词：
Biomechanics Mechanical Adaptation Remodeling Bone Intervertebral Disc Aorta Tendon リモデリング成長と変性

项目摘要

The biological issues and systems have the ability to grow, resorb, and/or deform themselves according to the changes of their environments and routine behaviors. Such ability of mechanical adaptation by remodeling is intrinsic only to the biological issue and systems. The quantitative observation and its model description are fundamental in understanding such phenomena and applying such a function in engineering field. From this viewpoint, this study investigates the following topics from experimental/mathematical approaches.1. Residual stress in bone and model of remodelingThe residual stress was released from the rabbit tibia-fibula system by the cutting method. It is found that the observed residual stress is comparable to that by the selfweight and its distribution is complex over the tibia. A model was proposed for the bone remodeling permitting the existence of the residual stress in the bone. The basic capability of the model was examined by simple case studies combined with the observed residual stress.2. Experimental spondylosis model and effect of overuseThe experimental spondylosis was established by surgicalintervention in mice. Mechanical instability accelerates the process of intervertebral disc degeneration and the long term instability brings the spondylosis. Repetitive extension-flexion was loaded on spine of rabbits, and the delamination of annulus fibrosus and the early osteophyte formation are observed. This suggests the overuse is a factor in the pathogenesis of spondylosis.3. Mechanical adaptation of aorta and patellar tendonGoldblatt hypertension was induced in rats and it is found that the aortic wall changes in morphology first and then in the mechanical properties adoptng itself to the mechanical environment. The stress shielding in the patellar tendon of rabbits leads the immediate decrease of the mechanical properties and the reloading brings the gradual recovery. These results show the rapid mechanical adaptation in soft tissues.

生物问题和系统具有根据其环境和日常行为的变化而生长、吸收和/或变形的能力。这种通过重塑实现机械适应的能力仅是生物问题和系统所固有的。定量观察及其模型描述是理解此类现象和在工程领域应用此类函数的基础。从这个角度来看，本研究从实验/数学方法研究了以下主题： 1．骨残余应力及重塑模型采用切割法释放兔胫腓骨系统的残余应力。结果发现，观察到的残余应力与自重产生的残余应力相当，并且其在胫骨上的分布很复杂。提出了一种允许骨中存在残余应力的骨重塑模型。通过简单的实例研究并结合残余应力观测结果检验了模型的基本性能。 2．实验性脊椎病模型及过度使用的效果通过手术干预小鼠建立实验性脊椎病。机械不稳定会加速椎间盘退变的过程，长期不稳定会导致脊椎病。对家兔脊柱进行反复伸屈加载，观察纤维环分层和早期骨赘形成。这表明过度使用是脊柱病发病的一个因素。3．主动脉和髌腱的机械适应在大鼠中诱导Goldblatt高血压，发现主动脉壁首先在形态上发生变化，然后在机械性能上发生变化以适应机械环境。兔髌腱的应力遮挡导致其力学性能立即下降，重新加载则逐渐恢复。这些结果显示了软组织的快速机械适应。