Correlations between Lefestyles and Mental- or Physical Health Status

生活方式与心理或身体健康状况之间的相关性

• 批准号: 02404034
• 负责人: MORIMOTO Kanehisa
• 金额: $ 1.47万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404034/
• 关键词: lifestyle; QOL; health status; chromosome aberration; sister chromatid exchange; aldehyde dehydrogenase; allergy; natural killer cell activity; ライフスタイル; 性格; 染色体変異; アルデヒド脱水素酵素; Natural Killer活性; 健康維持要因; ストレス量; エゴグラム; 精神的健康; 姉妹染色分体交換(SCE) /

1. In Japanese workers, lifestyles such as smoking. drinking, self-reported stress, physical exercise, mental health status including character and quality of life, and physical health status were comprehensively measured using questionnaires and physical examination data.2. In the same subjects, frequencies of sister-chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes were measured. Those who have good lifestyles had lower frequencies of SCE and lower enhancement ratios of CA frequencies by ara-C, compared to those with poor lifestyles. Genotypes of low Km ALDH2 were determined by the PCR method. Habitual drinkers who lack ALDH2 had significantly higher SCE frequency than non-habitual drinkers who lack ALDH2 or those who possess ALDH2 activity. Generally, alcohol-drinking bahaviors were strongly regulated by the ALDH2 activity.3. Natural killer (NK) activities were significantly higher in those with good lifestyles than those with poor lifestyles. Proportions of subsets of lymphocytes were also correlated with good lifestyles.4. Higher total IgE levels were significantly correlated with lifestyles, especially with smoking, and alcohol consumption.

1。在日本工人中，吸烟等生活方式。饮酒，自我报告的压力，体育锻炼，心理健康状况，包括特征和生活质量以及身体健康状况，并使用问卷和身体检查数据全面衡量。2。在同一受试者中，测量了外周淋巴细胞中姊妹染色剂交换（SCE）和染色体畸变（CA）的频率。与生活方式差的人相比，那些生活方式良好的人的SCE频率较低，而ARA-C的CA频率的增强率较低。低KM ALDH2的基因型通过PCR方法测定。缺乏ALDH2的惯常饮酒者的SCE频率明显高于缺乏ALDH2或拥有ALDH2活动的非汉堡饮用者。通常，饮酒的巴哈维尔人受Aldh2活性的强烈调节。3。与生活方式差的人相比，生活方式良好的人的自然杀手（NK）活动要高得多。淋巴细胞亚群的比例也与良好的生活方式相关。4。较高的总IgE水平与生活方式显着相关，尤其是吸烟和饮酒。

项目成果

森本 兼曩: "ライフスタイルと健康" 医学書院, 330 (1991)

森本兼弘：《生活方式与健康》医学书院，330（1991）

Takeshita,T.et al.: "Phenotypic clifferences in low km aldehyde dehydrogenase.in Japanese.workers" Lancet. 341. 837-838 (1993)

Takeshita,T.et al.：“日本工人中低 km 醛脱氢酶的表型悬崖”《柳叶刀》。

Hagihara, A., Kusaka, Y., Morimoto, K., Tamura, T. and Matsuura, Y.: "Health risk appraisal (HRA) and its educational effects on bank employees." Industrial Health. 30. 61-64 (1992)

Hagihara, A.、Kusaka, Y.、Morimoto, K.、Tamura, T. 和 Matsuura, Y.：“健康风险评估 (HRA) 及其对银行员工的教育影响。”

Morimoto, K.: Springer-Verlag, Berlin. Life-style and genetic factors that determine the susceptibility to production of chromosome damage. in ed. by Obe, G., Natarajan, A. T.: Chromosomal aberrations. Basic and applied aspects., 287-301 (1990)

Morimoto, K.：施普林格出版社，柏林。

森本 兼曩: "ライフスタイルと健康" 医学書院, 322 (1991)

森本兼弘：《生活方式与健康》医学书院，322（1991）