Co-operative Research on Boron-neutron capture therapy for various Malignant tumors

硼中子俘获治疗多种恶性肿瘤的合作研究

基本信息

批准号：
02304070
负责人：
HATANAKA Hiroshi
金额：
$ 8.96万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02304070/
关键词：
Cancer Boron-neutron capture therapy Boron Brain tumor Liver cancer Melanoma Bone cancer Neutron 多門照射重水メアノ-マ

项目摘要

Boron neutron capture therapy (BNCT) in Japan has been applied to treating more than 146 brain tumor patients since 1968 by Hatanaka and collaborators utilizing mercaptoundecaphydrododecaborate (BSH) at reactors of Musashi Institute of Technology, Kyoto University Reactor (KUR) and Japan Reactor-2 of Japan Atomic Energy Research Institute (JRR-2). BNCT is now being tried also by Oda of Kyoto University (9 cases) and by Nakagawa of Tokushima University (7 cases) at KUR since 1991. It has been also tried by Mishima (Kobe University) on 12 skin melanoma patients.Brain-stem tumors and skull base tumors, which have posed difficult problems in neurosurgery are being treated with the aid of heavy water and multiportal irradiation. Hatanaka has been also proving good effect ob BNCT upon giant cerebral arteriovenous malformation (AVM).For cancer of liver and abdominal viscerae, antibody to the tumor specific antigen has been considered a good carrier of boron-10 (Yanagie, Takahashi, Tokyo University).An encouraging result was obtained in animal experiment. Bone cancer have been studied by veterinary surgeons Takeuchi and Kadosawa at Tokyo University by using boronated derivative of porphyrins (BTPP) with satisfactory accumulation in the tumor tissue. BNCT appears to be a good device to treat difficult lesions in the brain and other organs which defy sophisticated modern therapeutic means.

自 1968 年以来，Hatanaka 及其合作者在武藏工业学院、京都大学 Reactor (KUR) 和 Japan Reactor-2 的反应堆中利用巯基十一氢十二硼酸盐 (BSH)，在日本使用硼中子俘获疗法 (BNCT) 治疗了超过 146 名脑肿瘤患者日本原子能研究所（JRR-2）的。自 1991 年起，京都大学的小田（9 例）和德岛大学的中川（7 例）也在 KUR 进行了 BNCT 试验。三岛（神户大学）也对 12 名皮肤黑色素瘤患者进行了试验。脑干肿瘤和颅底肿瘤一直是神经外科的难题，目前正在借助重水和多孔照射进行治疗。 Hatanaka 也被证明 BNCT 对巨大脑动静脉畸形 (AVM) 具有良好的效果。对于肝癌和腹部内脏癌，肿瘤特异性抗原的抗体被认为是硼 10 的良好载体（Yanagie、Takahashi、东京大学） .动物实验取得了令人鼓舞的结果。东京大学的兽医 Takeuchi 和 Kadosawa 使用硼化卟啉衍生物 (BTPP) 对骨癌进行了研究，在肿瘤组织中具有令人满意的积累。 BNCT 似乎是治疗大脑和其他器官中复杂的现代治疗手段无法解决的疑难病变的良好设备。