Applications of impedometry using micro - and nano - electrodes

使用微米和纳米电极的阻抗测量法的应用

• 批准号: 505364-2016
• 负责人: Goh, MCynthia
• 金额: $ 5.25万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=719282
• 关键词: Applications; impedometry; using; micro; nano

Universal NanoSensor Technologies (UNS-Tech) develops and commercializes nanochip and microfluidic impedance detectors. UNS-Tech's microfluidic conductivity detector for ion chromatography rivals the most sensitive currently available on the market but at a significantly lower price point. The nanochip is sensitive to material deposited on its surface at the sub monolayer level. It is manufactured using silicon fabrication methods and is also cost-effective. In this CRD project, UNS-Tech will partner with Prof. Cynthia Goh to extend and demonstrate the capacities of these technologies. The microfluidic detector's performance will be modeled using an equivalent resistor - capacitor model, which will then be exploited to extend its performance to include dielectric constant (DC) detection. DC is a universal property of matter, in turn making this detector a universal detector like a refractive index detector used in chromatography, but at a much lower price point and potentially with higher sensitivity. Also, in this project both the microfluidic and the nanochip detectors will be modified to enable them to function as sensors; i.e. they will be surface functionalized with molecular "recognition elements" that selectively bind to specific "targets", and the binding will be monitored using impedance spectroscopy. Applications of the new capabilities of both the microfluidic and nanochip technologies will be demonstrated, e.g. DC will be used to detect carbohydrates and polyethylene glycol and the sensors to detect crown ether/lead and biotin/avidin binding. The results will be analyzed and the findings will be published in scientific journals. Working with a company partner will provide students with invaluable real world experience developing products and enhance their training as highly qualified personnel as they prepare to enter the Canadian work force. UNS-Tech - an Ontario-based company - will also benefit. Achieving successful demonstrations in a university setting and publishing the results would be critical benchmarks for UNS-Tech before moving onto product development, beta tests and new product lines. This will require employing more Ontarians and will, in turn, benefit both Ontario and Canada.

Universal NanoSensor Technologies (UNS-Tech) 开发纳米芯片和微流体阻抗探测器并将其商业化。 UNS-Tech 的离子色谱微流体电导检测器可与目前市场上最灵敏的检测器相媲美，但价格却低得多。 纳米芯片对其表面亚单层沉积的材料敏感。 它采用硅制造方法制造，并且具有成本效益。 在这个 CRD 项目中，新南威尔士大学科技学院将与 Cynthia Goh 教授合作，扩展和展示这些技术的能力。微流体检测器的性能将使用等效电阻-电容器模型进行建模，然后利用该模型来扩展其性能以包括介电常数（DC）检测。 DC 是物质的通用属性，从而使该检测器成为通用检测器，如色谱中使用的折射率检测器，但价格低得多，并且可能具有更高的灵敏度。 此外，在这个项目中，微流体和纳米芯片探测器都将被修改，使它们能够充当传感器；即，它们将通过分子“识别元件”进行表面功能化，选择性地结合到特定的“目标”上，并且将使用阻抗谱来监测结合情况。 将展示微流体和纳米芯片技术新功能的应用，例如DC 将用于检测碳水化合物和聚乙二醇，传感器将用于检测冠醚/铅和生物素/亲和素结合。 结果将被分析，研究结果将发表在科学期刊上。与公司合作伙伴合作将为学生提供宝贵的产品开发实际经验，并在他们准备进入加拿大劳动力市场时加强他们作为高素质人才的培训。总部位于安大略省的 UNS-Tech 公司也将从中受益。在进入产品开发、Beta 测试和新产品线之前，在大学环境中实现成功的演示并发布结果将是 UNS-Tech 的关键基准。 这将需要雇用更多的安大略人，反过来将使安大略省和加拿大受益。