Clinical Application of Dipole Tracing Method Estimating Electric Generator Source in the Brain.

偶极子追踪方法估计脑内发电机源的临床应用。

• 批准号: 01044026
• 负责人: HOMMA Saburo
• 金额: --
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Overseas Scientific Survey.
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01044026/
• 关键词: Dipole Tracing Method; Epileptic Potential; Generator Mechanism; Hippocampus; Correction Factor; Source Localization

Using the Dipole Tracing System, which we have developed and is non-invasive method to estimate electrical sources in the human brain from conventional EEG recordings, we have performed research works on three patients suffering from intractable epileptic seizure in University Hospital Uppsala, Sweden. The following findings were obtained from the research works.We have estimated dipole locations and vector moments of interictal convexity sharp waves recorded (with conventional EEG technique) from the right fronto-temporal region in a patient with partial complex seizures. When the dipole locations in the head model were compared to MRI scans, the majority of the sharp wave dipoles were found to be located in the right hippocampal area. Previous long-term subdural recording had shown seizure onset in this area. These findings will be published in Neuroscience Letters in 1990.We have obtained correction factors from three-dimensional X-ray images of the subdural electrodes and estimated locations of the dipoles artificially elicited on the subdural electrodes. These findings will be published in IEEE Transaction of Biomedical Engineering in 1990.

我们使用我们已经开发的偶极子示踪系统，是从常规的脑电图记录中估算人脑电源的无创方法，我们对三名患者在瑞典Uppsala大学医院的顽固性癫痫发作的患者进行了研究工作。从研究工作中获得了以下发现。我们估计有右额额 - 颞型区域中记录的偶极偶发性凸起尖锐波的矢量矩和偏向于部分复杂癫痫的患者的载体矩。当将头模型中的偶极子位置与MRI扫描进行比较时，发现大多数锋利的波浪偶极子位于右海马区域。以前的长期硬膜下记录显示了该地区的癫痫发作。这些发现将于1990年发表在神经科学字母中。我们从硬膜下电极的三维X射线图像中获得了校正因子，并在下硬膜下电极上人为地引起了偶极子的估计位置。这些发现将于1990年发表在生物医学工程的IEEE交易中。

项目成果

Musha T,Homma S,Nakajima Y,Okamoto Y,Hagbarth K-E,Blom S & Flink R: "Effects of the skull on equivalent dipole location in the homogeneous conductor model of realistic head geometry." IEEE Transactions of Biomedical Engineering.(1990)

Musha T、Homma S、Nakajima Y、Okamoto Y、Hagbarth K-E、Blom S

Homma S,Nakajima Y,Musha T,Okamoto Y,Hagbarth K-E,Blom S & Flink R: "Generator mechanisms of epileptic potentials analyzed by dipole tracing method." NEUROSCIENCE LETTERS. (1990)

Homma S、Nakajima Y、Musha T、Okamoto Y、Hagbarth K-E、Blom S

Musha T, Homma S, Nakajima Y, Okamoto Y, Hagbarth K-E, Blom S and Flink R.: "Effects of the Skull on Equivalent Dipole Location in the Homogeneous Conductor Model of Realistic Head Geometry." IEEE Transactions of Biomedical Engineering.(1990)

Musha T、Homma S、Nakajima Y、Okamoto Y、Hagbarth K-E、Blom S 和 Flink R.：“头骨对现实头部几何形状的均匀导体模型中等效偶极子位置的影响”。

Homma S, Nakajima Y, Musha T, Okamoto Y, Hagbarth K-E, Blom S and Flink R.: "Generator Mechanisms of Epileptic Potentials Analyzed by Dipole Tracing Method." Neuroscience Letters.(1990)

Homma S、Nakajima Y、Musha T、Okamoto Y、Hagbarth K-E、Blom S 和 Flink R.：“通过偶极子追踪方法分析癫痫电位的发生器机制”。

Homma S, Nakajima Y, Musha T, Okamoto Y, Hagbarth K-E, Blom S and Flink R.: "Generator Mechanisms of Epileptic Potentials analyzed by Two-Dipole Estimation." Neuroscience Letters.(1990)

Homma S、Nakajima Y、Musha T、Okamoto Y、Hagbarth K-E、Blom S 和 Flink R.：“通过二偶极估计分析癫痫电位的生成机制”。