Anti-inflammatory and immunomodulatory action of eicosapentaenoic acid (EPA)

二十碳五烯酸 (EPA) 的抗炎和免疫调节作用

• 批准号: 63440041
• 负责人: YOSHIDA Sho
• 金额: $ 9.73万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63440041/
• 关键词: Eicosapentaenoic acid; Arachidonic acid; Psoriasis; Cytokine; Eicosanoids; Mononuclear cell; Leukotriene B_4; Chronic inflammatory bowel disease; エイコサペンタコン酸; 潰瘍性大腸炎; クロ-ン病; サイトカイン; 多価不飽和脂肪酸; エイコサペンタエン酸; ナチュラルキラ-細胞; ロイコトリエンB; ナチュナルキラ-細胞; マ

EPA rich-spleen cells obtained from rats fed with highly rified EPA-ethylester (EPA-E) showed a decrease in natural killer cell (NKC) activity with reduction of LTB_4 production. Exogenous addition of LTB_4 restored NKC activity. A potency of LTB_5 derived from EPA in NKC activity and cytokine production is far less than that of LTB_4 derived from AA. This might be due to a weaker binding affinity of LTB_5 to cell membrance receptor than that of LTB_4. EPA administration of EPA prevented the development of carrageneen-induced ulcerative colitis in guinea pig. In chromic inflammatory bowel diseases (CBD) such as Crohn's disease and ulcerative colitis, there is an enhanced production of cytokines such as lL-1B. lL-2 and lL-6 in mononuclear leucocytes obtained from the patients with active CBD. Oral administration of purified EPA reduced the production of LTB_4 in mononuclear leucocytes and improved the skin lesion of patrints with psoriasis.There research results rlescribed above apparently indiate that EPA has also anti-inflammatory and immunomodulatory action and may have a beneficial effect on chromic inflammatory autoimmune diseases.

EPA富含富含EPA-乙基酯（EPA-E）的大鼠获得的EPA富集细胞显示自然杀伤细胞（NKC）活性降低，LTB_4产生的降低。 LTB_4的外源添加恢复了NKC活性。 NKC活性和细胞因子产生中EPA衍生的LTB_5的效力远小于源自AA的LTB_4。这可能是由于LTB_5与细胞膜受体的结合亲和力较弱，而LTB_4的结合亲和力。 EPA的EPA防止了豚鼠中卡拉氏蛋白酶引起的溃疡性结肠炎的发展。在Crohn疾病和溃疡性结肠炎等染色性炎症性肠道疾病（CBD）中，LL-1B等细胞因子的产生增强。从活性CBD患者获得的单核白细胞中的LL-2和LL-6。口服纯化的EPA降低了单核白细胞中LTB_4的产生，并改善了牛皮癣的皮肤病变。上面的研究结果表明，EPA显然还具有抗炎和免疫调节作用，并且可能对彩色炎症性炎症性自动症具有有益的作用疾病。

项目成果

Chang KJ,Saito H,Tamura Y,Watanabe K & Yoshida S.: "Effect of oral ingertion of EPA-lthylester on natural killer celloctirity in rat spleen cells" prostaglandin,Leuiotirncs and Essential Fatty Acids. 38. 87-90 (1989)

张 KJ、齐藤 H、田村 Y、渡边 K

Kitsukawa Y.Sito H.Suzuki Y.Kasanuki J.Tamura Y and Yoshida S.: "Effect of EPA-ethyl ester in earraseenan-mduced.lolifis, in guinea Pig" Gastrosuterolsgy. (1992)

Kitsukawa Y.Sito H.Suzuki Y.Kasanuki J.Tamura Y 和 Yoshida S.：“EPA-乙酯对豚鼠earraseenan-mduced.lolifis 的影响”Gastrosuterolsgy。

Chang K.J.,Saitoh H.,Tatsuno I.,Tamura Y.,Watanabe K.,&Yoshida S.: "Composition of the effect of lipoxygenase metabolites of arachidonio acid and eicosapentaenoic acid on human natural killer cell cytoーtoxicity." Prostaglandins Leucotriens and Essential F

Chang K.J.、Saitoh H.、Tatsuno I.、Tamura Y.、Watanabe K. 和 Yoshida S.：“花生四烯酸和二十碳五烯酸的脂氧合酶代谢物对人类自然杀伤细胞前列腺素白三烯和必需素的影响的组成。” F

張克堅,斎藤博幸,寺野隆,田村泰,吉田尚: "ラット脾細胞ナチュナルキラ-活性におけるアラキドン酸の5リポキシゲナ-ゼ代謝産物の作用機序" 炎症. 9. 103-106 (1989)

Kejian 张、Hiroyuki Saito、Takashi Terano、Yasushi Tamura、Hisashi Yoshida：“花生四烯酸 5-脂氧合酶代谢物对大鼠脾细胞天然 chila 活性的作用机制”炎症。

Tamura, Y., Hirai, A., Terano, T. and Yoshida, S.: "Clinical and epidemiological studies of omega-3 polyunsaturated fatty acids in Japan." Nutritional Support in Organ Failure. Elsevier Science Pub. (1990)

Tamura, Y.、Hirai, A.、Terano, T. 和 Yoshida, S.：“日本 omega-3 多不饱和脂肪酸的临床和流行病学研究。”