Human Evoked Response and EEG Changes to Odorant Stimulation

人类对气味刺激的诱发反应和脑电图变化

基本信息

批准号：
62570790
负责人：
KATO Toshihiko
金额：
$ 1.15万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

The summary of the results of our study which took place from 1987 to 1988 are described. An apparatus was developed allowing control of stimulation for recording odorant evoked response from the human scalp. The characteristics of the apparatus were as follows. 1) A sensor was attached to the nostril allowing translation of the subject's respiration into electrical signals. 2)The period and timing of odorant stimuli were adjustable allowing stimuli to be given synchronous with respirations. 3)The intervals of odorant stimulation could be arbitrarily selected to occur every 1 to 9 respiration(s) allowing avoidance of adaptation to the given odor.Odorant evoked responses were obtained in 84.6% of the 26 normal subjects tested. The responses were classified into three types, with a peak latently of 300 msec, 700 msec, and both latencies. The scalp distribution of responses revealed that the region of high potentials were widely spread over the vertex, and that latency with distance towards the occipital region. A response was not recordable from a patient with anosmia. However, more study is necessary to apply this finding to objective olfactometry because that the responses were not recorded in all normal subjects.The EUG changes during odorant stimulation were investigated using the technique of SPN (significance probability mapping). The findings allowed that alpha _1, delta and rheta waves were decreased in the occipital region and that alpha_2 wave was increased at the frontal region. These EEG changes may reflect activity of the olfactory central system in the frontal region.

描述了1987年至1988年进行的研究结果的摘要。开发了一种设备，可以控制刺激以记录人类头皮的气味诱发反应。设备的特征如下。 1）将传感器连接到鼻孔，允许将受试者的呼吸转化为电信号。 2）可调气味刺激的时期和时机可以使刺激与呼吸同步。 3）可以任意选择一次气味刺激的间隔，以避免适应给定气味的每1至9个呼吸。响应分为三种类型，峰值为300毫秒，700毫秒和两个潜伏期。响应的头皮分布表明，高电位区域广泛分布在顶点，并且距离距枕骨区域的距离的潜伏期。厌食症患者无法记录反应。但是，需要更多的研究将此发现应用于客观的嗅觉法，因为在所有正常受试者中均未记录响应。使用SPN技术（显着性概率映射）研究了气味刺激过程中的EUG变化。研究结果允许枕骨区域α，三角洲和rheta波减少，并且在额叶区域增加了α_2波。这些脑电图的变化可能反映了额叶区域嗅觉中心系统的活性。