Ultrastructural and physiological studies on the function of pituitary intermediate lobe in mice.
小鼠垂体中叶功能的超微结构和生理学研究。
基本信息
- 批准号:62540568
- 负责人:
- 金额:$ 1.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1987
- 资助国家:日本
- 起止时间:1987 至 1989
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The present studies demonstrated a new fact that oral urea administration resulted in hypersecretion of pituitary intermediate lobe(PIL) cells in mice. Oral urea is the third factor, besides our previous studies of dietary Na-deficiency (1974,1976) wid of experimental polydipsia (1984), that stimulates PIL cells in fine structure. The outline of the ultrastructural and morphometric studies is described as follows:(1) Alterations in PIL cells of suckling mice fed a liquid diet supplemented with 1% urea. Suckling dams (day 12-17 of lactation) were fed with either a liquid diet (11.5% powdered milk) or the liquid diet containing 1% urea. Morphometric study resulted in the hypersecretion in PIL cells of dams being given the urea-containing liquid diet more significantly than that of the liquid diet control.(2) Alterations in PIL cells of male mice fed a liquid diet supplemented with 1% urea. Young adult male mice were fed with the liquid diet containing 1% urea for 10 days in order to ascertain whether oral urea could stimulate PIL cells not only in lactating dams but also in male mice. The morphometric analysis showed the result that oral urea stimulated significantly the secretory activity of PIL cells in male mice.(3) Alerations in PIL cells of male mice given the pelleted food containing urea in the concentration of 6%, 12% and 24% for 14 days. Morphometric result revealed the increment of segretion activity in PIL cells of mice given urea- containing pellets in a dose dependent manner. Water consumption also increased in parallel to the urea concentrations adopted. These results are interpreted that oral urea stimulation of PIL cells is through a mechanism of either (1)attenuation of hypothalamic inhibitory control over PIL cells or (2)an involvement of PI hormones in the excretion of excess urea, or (3) hyponatremia caused by high blood urea concentration.
本研究表明,口服尿素给药导致小鼠中垂体中间叶(PIL)细胞的分泌。口服尿素是第三个因素,除了我们先前对饮食NA缺乏症的研究(1974,1976)的实验多磷酸(1984),还刺激了PIL细胞的精细结构。超微结构和形态学研究的轮廓如下:(1)喂食补充1%尿素的液体饮食的PIL细胞的改变。用液体饮食(11.5%粉末牛奶)或含有1%尿素的液体饮食喂食哺乳水坝(泌乳的第12-17天)。形态计量学研究导致在大坝的PIL细胞中的过度分泌,含尿素的液体饮食比液体饮食控制的含量更明显。(2)喂食含有1%尿素的液体饮食的雄性小鼠的PIL细胞改变。将年轻的成年雄性小鼠用含有1%尿素的液体饮食喂食10天,以确定口服尿素是否可以刺激PIL细胞不仅在泌乳大坝中,而且还可以在雄性小鼠中刺激。形态分析表明,口服尿素在雄性小鼠中显着刺激了PIL细胞的分泌活性。(3)雄性小鼠的PIL细胞中含有含有尿素的尿素浓度为6%,12%和24%的雄性小鼠的PIL细胞,为14天。形态测定结果表明,以剂量依赖性方式给予尿素的小鼠的PIL细胞中脱生活性的增加。用水量也与采用的尿素浓度并行增加。这些结果解释说,口服尿素刺激PIL细胞是通过(1)(1)下丘脑对PIL细胞的抑制性控制的机制,或(2)PI激素参与过量尿素的排泄,或(3)低血液尿素浓度引起的低钠血症。
项目成果
期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kobayashi, Y. and A. Tanaka: "Effects of maternal copious drinking on pup's pituitary intermediate lobe cells in mice." Biomed. Res.
Kobayashi, Y. 和 A. Tanaka:“母亲大量饮酒对小鼠幼仔垂体中叶细胞的影响。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
YASUO KOBAYASHI and MANABU OKADA: "A morphometric study on pituitary pars intermedia cells of mice fed liquid diet supplemented with urea" Zoological Science.
Yasuo KOBAYASHI 和 MANABU OKADA:“对补充尿素的流质饮食的小鼠垂体中间部细胞的形态测量研究”《动物学科学》。
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
YASUO KOBAYASHI,and AKIKO TANAKA: "Effects of maternal copious drinking on pup's pituitary intermediate lobe cells in mice" Biomedical Research.
YASUO KOBAYASHI 和 AKIKO TANAKA:“母亲大量饮酒对小鼠幼崽垂体中叶细胞的影响”生物医学研究。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
Kobayashi, Y. and M. Okada: "Urea stimulation of pituitary pars intermedia cells of suckling mice under copious drinking." Zool. Sci.7(2). (1990)
Kobayashi, Y. 和 M. Okada:“尿素对大量饮酒下乳鼠垂体中间部细胞的刺激。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
Kobayashi, Y. and M. Okada: "Effect of NaCl under excess drinking on fine structural alterations in mouse pituitary pars intermedia cells." Biomed. Res.
Kobayashi, Y. 和 M. Okada:“过量饮酒下的氯化钠对小鼠垂体中间部细胞精细结构改变的影响。”
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- 影响因子:0
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KOBAYASHI Yasuo其他文献
KOBAYASHI Yasuo的其他文献
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{{ truncateString('KOBAYASHI Yasuo', 18)}}的其他基金
Development of rumen microbial profiling to identify low methane-producing cattle
开发瘤胃微生物分析以识别低甲烷产生牛
- 批准号:
23380156 - 财政年份:2011
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of a fiber supplement to improve fiber digestion in ruminants
开发纤维补充剂以改善反刍动物的纤维消化
- 批准号:
23658213 - 财政年份:2011
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of innovative rumen modifier to reduce methane production
开发创新型瘤胃改良剂以减少甲烷产生
- 批准号:
20380146 - 财政年份:2008
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Challenges to explore uncultivable but functional bacteria in the rumen
探索瘤胃中不可培养但有功能的细菌的挑战
- 批准号:
15580231 - 财政年份:2003
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of ecology of rumen bacterial populations by molecular biological techniques
通过分子生物学技术分析瘤胃细菌种群的生态学
- 批准号:
11660284 - 财政年份:1999
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Tracking of recombinant rumen bacterium by indecular method using target 16S rRNA sequence
使用目标 16S rRNA 序列通过内嵌法追踪重组瘤胃细菌
- 批准号:
09660302 - 财政年份:1997
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular Breeding of Highly Fibrolytic Rumen Bacteria with newly developed transformation system.
采用新开发的转化系统进行高度纤维溶解瘤胃细菌的分子育种。
- 批准号:
07660377 - 财政年份:1995
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Chromosome partitioning at the initiation of sporulation in Bacillus subtilis
枯草芽孢杆菌孢子形成起始时的染色体分配
- 批准号:
07456048 - 财政年份:1995
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Research on Management of Japanese Manufacturing Industries, Which have Invested Overseas.
日本制造业对外投资管理研究。
- 批准号:
04301083 - 财政年份:1992
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Bacterial differentiation: Its application on production of useful substances.
细菌分化:其在有用物质生产中的应用。
- 批准号:
60303024 - 财政年份:1985
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
相似海外基金
Morphological study on human intermediate lobe of the pituitary, and its lesion
人垂体中叶及其病变的形态学研究
- 批准号:
63570680 - 财政年份:1988
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)